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引用次数: 0
摘要
目的：已知干燥病（SjD）患者可发展为萎缩性胃炎。我们的目的是研究萎缩性胃炎在SjD患者中的患病率及其与幽门螺杆菌感染和自身抗体的关系。方法：收集2004年1月至2024年6月在我院行上内镜检查的SjD患者103例资料。通过脲酶试验、13c -尿素呼气试验和血液幽门螺杆菌抗体试验中至少一种方法检测幽门螺杆菌感染。结果：SjD患者中萎缩性胃炎患病率为68.0%。约一半（56.1%）萎缩性胃炎患者幽门螺杆菌检测呈阳性。原发性SjD合并萎缩性胃炎患者抗la /SSB抗体阳性率明显高于其他胃检查结果的患者（38.5% vs. 5.9%）。结论：除幽门螺杆菌外，抗la /SSB抗体可能与原发性SjD患者萎缩性胃炎的发生有关。
A study of clinical features of atrophic gastritis in patients with Sjögren's disease.
Objectives: Patients with Sjogren's disease (SjD) are known to develop atrophic gastritis. Our aim is to examine the prevalence rate of atrophic gastritis in patients with SjD and its association with Helicobacter pylori infection and autoantibodies.
Methods: We collected data of 103 patients with SjD, who underwent upper endoscopy at our hospital from January 2004 to June 2024. Helicobacter pylori infection was determined by at least one of the following methods, the urease test, the 13C-urea breath test, and the blood test for H. pylori antibody.
Results: The prevalence rate of atrophic gastritis in patients with SjD was 68.0%. Around half of the patients (56.1%) with atrophic gastritis were positive for H. pylori tests. Primary SjD patients with atrophic gastritis had significantly higher positive rates of anti-La/SSB antibody than those with other gastric findings (38.5% vs. 5.9%, P < .05). There was no difference in anti-La/SSB antibody prevalence between H. pylori positive and negative group.
Conclusion: Anti-La/SSB antibody, other than H. pylori may contribute to develop atrophic gastritis in patients with primary SjD.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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