Maria von Stumm, Gregory Heger, Julia Danner, Zahra Alalawi, Cordula Wolf, Katarzyna Gendera, Stanimir Georgiev, Peter Ewert, Jürgen Hörer, Julie Cleuziou
{"title":"法洛氏四联症修复术后残留的肺动脉瓣病变--狭窄比反流好吗?","authors":"Maria von Stumm, Gregory Heger, Julia Danner, Zahra Alalawi, Cordula Wolf, Katarzyna Gendera, Stanimir Georgiev, Peter Ewert, Jürgen Hörer, Julie Cleuziou","doi":"10.1177/21501351251321533","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundResidual pulmonary valve disease (PVD) including pulmonary stenosis (PS), pulmonary regurgitation (PR), or both remains a known complication following repair of Tetralogy of Fallot (TOF). We sought to clarify prevalence, progression, and prognostic impact of residual PVD.MethodsWe identified consecutive patients who underwent repair of TOF at our institution between January 2004 and July 2023. Based on echocardiographic measurements following repair, residual PVD was defined: nonsevere PVD (PS < 25 mm Hg; PR<Grade3), isolated PS (PS ≥ 25 mm Hg; PR<Grade3), isolated PR (PS < 25 mm Hg; PR ≥ Grade3), and mixed PVD (PS ≥ 25 mm Hg; PR ≥ Grade3). Primary study endpoint was the composite of reoperation and catheter-based reintervention.ResultsA total of 244 patients (median age 6 months) were included. Mean follow-up time was 9 ± 5 years. At discharge, 54 patients (23%) showed nonsevere PVD, PS (n = 62, 26%), PR (n = 63, 26%), or mixed PVD (n = 61, 25%). Freedom from primary endpoint was 92 ± 2% and 88 ± 2% at 5 and 10 years, respectively for all patients with residual PVD. There was no significant difference between patients with PS and PR at 10 years (PS, 86 ± 5% vs PR, 93 ± 4%; log-rank test, <i>P</i> = .85). Multivariable analysis demonstrated a significant association between mixed PVD and the primary study endpoint.ConclusionAlthough residual PVD was frequent in patients following TOF repair, freedom from reintervention and reoperation was acceptable at midterm. Residual PS did not protect from reoperation or reintervention when compared with residual PR. The combination of PS and PR was identified as arisk factor for reoperation and reintervention<i>.</i></p>","PeriodicalId":94270,"journal":{"name":"World journal for pediatric & congenital heart surgery","volume":" ","pages":"21501351251321533"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Residual Pulmonary Valve Disease Following Repair of Tetralogy of Fallot-Is Stenosis Better Than Regurgitation?\",\"authors\":\"Maria von Stumm, Gregory Heger, Julia Danner, Zahra Alalawi, Cordula Wolf, Katarzyna Gendera, Stanimir Georgiev, Peter Ewert, Jürgen Hörer, Julie Cleuziou\",\"doi\":\"10.1177/21501351251321533\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundResidual pulmonary valve disease (PVD) including pulmonary stenosis (PS), pulmonary regurgitation (PR), or both remains a known complication following repair of Tetralogy of Fallot (TOF). We sought to clarify prevalence, progression, and prognostic impact of residual PVD.MethodsWe identified consecutive patients who underwent repair of TOF at our institution between January 2004 and July 2023. Based on echocardiographic measurements following repair, residual PVD was defined: nonsevere PVD (PS < 25 mm Hg; PR<Grade3), isolated PS (PS ≥ 25 mm Hg; PR<Grade3), isolated PR (PS < 25 mm Hg; PR ≥ Grade3), and mixed PVD (PS ≥ 25 mm Hg; PR ≥ Grade3). Primary study endpoint was the composite of reoperation and catheter-based reintervention.ResultsA total of 244 patients (median age 6 months) were included. Mean follow-up time was 9 ± 5 years. At discharge, 54 patients (23%) showed nonsevere PVD, PS (n = 62, 26%), PR (n = 63, 26%), or mixed PVD (n = 61, 25%). Freedom from primary endpoint was 92 ± 2% and 88 ± 2% at 5 and 10 years, respectively for all patients with residual PVD. There was no significant difference between patients with PS and PR at 10 years (PS, 86 ± 5% vs PR, 93 ± 4%; log-rank test, <i>P</i> = .85). Multivariable analysis demonstrated a significant association between mixed PVD and the primary study endpoint.ConclusionAlthough residual PVD was frequent in patients following TOF repair, freedom from reintervention and reoperation was acceptable at midterm. Residual PS did not protect from reoperation or reintervention when compared with residual PR. The combination of PS and PR was identified as arisk factor for reoperation and reintervention<i>.</i></p>\",\"PeriodicalId\":94270,\"journal\":{\"name\":\"World journal for pediatric & congenital heart surgery\",\"volume\":\" \",\"pages\":\"21501351251321533\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal for pediatric & congenital heart surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/21501351251321533\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal for pediatric & congenital heart surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/21501351251321533","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:残余肺瓣膜疾病(PVD)包括肺动脉狭窄(PS)、肺反流(PR),或两者兼有,仍然是法洛四联症(TOF)修复后已知的并发症。我们试图澄清残余PVD的患病率、进展和预后影响。方法选取2004年1月至2023年7月在我院连续行TOF修复术的患者。根据修复后超声心动图测量,残余PVD定义为:非严重PVD (PS < 25 mm Hg;prp = .85)。多变量分析表明混合PVD与主要研究终点之间存在显著关联。结论虽然TOF术后PVD残留较多,但中期无再干预和再手术是可以接受的。与残留的PR相比,残留的PS对再手术和再干预没有保护作用。PS和PR的联合被认为是再手术和再干预的危险因素。
Residual Pulmonary Valve Disease Following Repair of Tetralogy of Fallot-Is Stenosis Better Than Regurgitation?
BackgroundResidual pulmonary valve disease (PVD) including pulmonary stenosis (PS), pulmonary regurgitation (PR), or both remains a known complication following repair of Tetralogy of Fallot (TOF). We sought to clarify prevalence, progression, and prognostic impact of residual PVD.MethodsWe identified consecutive patients who underwent repair of TOF at our institution between January 2004 and July 2023. Based on echocardiographic measurements following repair, residual PVD was defined: nonsevere PVD (PS < 25 mm Hg; PRP = .85). Multivariable analysis demonstrated a significant association between mixed PVD and the primary study endpoint.ConclusionAlthough residual PVD was frequent in patients following TOF repair, freedom from reintervention and reoperation was acceptable at midterm. Residual PS did not protect from reoperation or reintervention when compared with residual PR. The combination of PS and PR was identified as arisk factor for reoperation and reintervention.