计算得出的亲子互动模式和催产素在有和没有强迫症的儿童中的作用。

IF 4.8 2区医学 Q1 PSYCHIATRY

Journal of Anxiety Disorders Pub Date : 2025-03-03 DOI:10.1016/j.janxdis.2025.102996

Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt

{"title":"计算得出的亲子互动模式和催产素在有和没有强迫症的儿童中的作用。","authors":"Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt","doi":"10.1016/j.janxdis.2025.102996","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.</div></div><div><h3>Methods</h3><div>We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.</div></div><div><h3>Results</h3><div>Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns \"overinvolved interaction\" and \"emotional interaction\" and a negative association with \"distant interaction\". Additionally, mother oxytocin was positively associated with \"supportive interaction\" and \"varied-coping interaction\", and negatively associated with \"conflictual interaction\" and \"negative-low support interaction\". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.</div></div><div><h3>Conclusion</h3><div>Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102996"},"PeriodicalIF":4.8000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD\",\"authors\":\"Anna-Rosa Cecilie Mora-Jensen , Christine Lykke Thoustrup , Eli R. Lebowitz , Julie Hagstrøm , Linea Pretzmann , Nicoline Løcke Jepsen Korsbjerg , Emilie Damløv Thorsen , Valdemar Funch Uhre , Sofie Heidenheim Christensen , Camilla Uhre , Melanie Ritter , Kerstin J. Plessen , Anne Katrine Pagsberg , Line Katrine Harder Clemmensen , Nicole Nadine Lønfeldt\",\"doi\":\"10.1016/j.janxdis.2025.102996\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.</div></div><div><h3>Methods</h3><div>We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.</div></div><div><h3>Results</h3><div>Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns \\\"overinvolved interaction\\\" and \\\"emotional interaction\\\" and a negative association with \\\"distant interaction\\\". Additionally, mother oxytocin was positively associated with \\\"supportive interaction\\\" and \\\"varied-coping interaction\\\", and negatively associated with \\\"conflictual interaction\\\" and \\\"negative-low support interaction\\\". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.</div></div><div><h3>Conclusion</h3><div>Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.</div></div>\",\"PeriodicalId\":48390,\"journal\":{\"name\":\"Journal of Anxiety Disorders\",\"volume\":\"111 \",\"pages\":\"Article 102996\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Anxiety Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0887618525000325\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Anxiety Disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0887618525000325","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

背景：亲子互动过程是儿童强迫症的重要影响因素。了解亲子互动行为的生物学机制有助于改善儿童强迫症的治疗。催产素被认为是亲子互动的一种生物学机制。然而，目前还没有关于儿童强迫症的研究。我们使用机器学习来发现亲子互动行为的潜在模式，并探索有或没有强迫症的儿童与催产素的关系。方法：我们使用酶联免疫吸附试验（ELISA）测量父母和儿童唾液催产素水平，并在挫折任务中研究者评估父母和儿童的行为。有或没有强迫症的儿童及其父母——包括107对母子和62对父子。我们使用了两种机器学习技术，主成分分析和原型分析，来生成数据驱动的，理论不可知的行为变量，并回归来估计它们与催产素的关系。结果：主成分和原型分析确定了描述母子和父子互动的行为模式。我们发现母子间的催产素与“过度介入互动”和“情感互动”的互动模式呈正相关，与“远距离互动”的互动模式呈负相关。此外，母亲催产素与“支持互动”和“可变应对互动”呈正相关，与“冲突互动”和“负低支持互动”负相关。父亲催产素仅在儿童患有强迫症时才与“支持性互动”有关。结论：儿童和母亲催产素与母子互动模式有关。父亲的催产素只与强迫症儿童的互动模式有关。我们的探索性发现可以为未来关于催产素与强迫症患者不适应家庭参与之间的关系以及孩子患有强迫症时父母行为差异的研究提供假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD

Background

Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.

Methods

We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.

Results

Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns "overinvolved interaction" and "emotional interaction" and a negative association with "distant interaction". Additionally, mother oxytocin was positively associated with "supportive interaction" and "varied-coping interaction", and negatively associated with "conflictual interaction" and "negative-low support interaction". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.

Conclusion

Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Anxiety Disorders Multiple-

CiteScore

16.60

自引率

2.90%

发文量

期刊介绍： The Journal of Anxiety Disorders is an interdisciplinary journal that publishes research papers on all aspects of anxiety disorders for individuals of all age groups, including children, adolescents, adults, and the elderly. Manuscripts that focus on disorders previously classified as anxiety disorders such as obsessive-compulsive disorder and posttraumatic stress disorder, as well as the new category of illness anxiety disorder, are also within the scope of the journal. The research areas of focus include traditional, behavioral, cognitive, and biological assessment; diagnosis and classification; psychosocial and psychopharmacological treatment; genetics; epidemiology; and prevention. The journal welcomes theoretical and review articles that significantly contribute to current knowledge in the field. It is abstracted and indexed in various databases such as Elsevier, BIOBASE, PubMed/Medline, PsycINFO, BIOSIS Citation Index, BRS Data, Current Contents - Social & Behavioral Sciences, Pascal Francis, Scopus, and Google Scholar.