Investigation of the clinical effects of isoxsuprine hydrochloride administered before cesarean section in sheep on mother and newborn

The present study was conducted to determine the clinical effects of isoxsuprine hydrochloride (IP) administered prior to elective and emergency cesarean operations on the mother and newborn. The study was carried out on 40 pregnant Awassi sheep aged 2 years, divided into two operation groups: elective cesarean and emergency cesarean. From these groups, a total of four groups were formed: Group I (n = 10), which received 5 mL saline solution 45 min before the cesarean operation; Group II (n = 10), which received 0.6 mg/kg IP 45 min before the cesarean operation; Group III (n = 10), which received 16 mg dexamethasone 24 h before the cesarean operation; and Group IV (n = 10), which received 16 mg dexamethasone 24 h before and 0.6 mg/kg IP 45 min before the cesarean operation. Preoperative Doppler ultrasound measurements were performed on the uterine artery, umbilical artery, fetal aorta, ductus venosus, fetal vena cava, and placentome arteries. Both preoperative and postoperative oxidative stress parameters, as well as postoperative blood gas and APGAR parameters, were evaluated. In the groups administered isoxsuprine, PI and RI values of the measured vessels decreased, while PSV, EDV, and A values increased significantly (p < 0.001). Blood gas parameters such as pH, pO₂, and HCO₃ levels were higher, whereas pCO₂ levels were lower in the isoxsuprine-treated groups. Lambs born to the isoxsuprine-treated groups exhibited higher APGAR scores (p < 0.05). Furthermore, antioxidant capacities (TAS) were higher, and oxidative stress levels (TOS, OSI) were lower in lambs from the isoxsuprine-treated groups (p < 0.001). In conclusion, isoxsuprine administration improved maternal and fetal circulation, enhancing blood flow and positively affecting offspring viability.