右侧背外侧前额叶皮层和海马亚区的内在功能连接与侵入性创伤记忆的情感和感觉知觉特性有关。

Quentin Devignes, Kevin J Clancy, Boyu Ren, Yara Pollmann, Justin T Baker, Isabelle M Rosso
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引用次数: 0

摘要

背景:创伤相关侵入性记忆(TR-IMs)是创伤后应激障碍(PTSD)的核心症状。先前的研究将症状重现与右背外侧前额叶皮层(dlPFC)和右海马之间的静息状态功能耦合联系起来。然而,之前的研究并没有研究这种负耦合是否与TR-IMs有关,也没有区分前海马和后海马(aHPC/pHPC)。本研究探讨了有症状的创伤暴露TR-IMs个体的TR-IM频率和性质与静息状态下右侧dlPFC和右侧aHPC/pHPC负耦合的关系。方法:参与者(N=109;88名女性)完成了为期两周的生态瞬时评估,记录了TR-IM的频率和特性(侵入性、情绪强度、生动性、视觉特性和重现性)。通过静息状态功能磁共振成像,将参与者特异性的4毫米球体放置在与右侧aHPC和pHPC最不相关的右侧dlPFC体素上。准泊松和线性混合效应模型评估了TR-IM频率和性能与右dlpfc -右aHPC和pHPC反相关的关系。结果:TR-IM情绪强度与右侧dlPFC-aHPC连通性呈正相关,生动度和视觉特性与右侧dlPFC-pHPC连通性相关。在控制创伤后应激障碍症状严重程度和创伤后时间后,这些关联仍然显著。TR-IM频率、侵入性或缓解之间没有显着关联,并且与任何海马亚区都不相关。结论:本研究为TR-IMs的神经相关性提供了新的见解,强调了右侧dlPFC和aHPC/pHPC之间的内在负耦合与其现象学的相关性。对这一回路的进一步研究可以促进对创伤再体验的组成过程的理解,创伤再体验是一种严重且难以治疗的创伤后应激障碍症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intrinsic Functional Connectivity of Right Dorsolateral Prefrontal Cortex and Hippocampus Subregions Relates to Emotional and Sensory-Perceptual Properties of Intrusive Trauma Memories.

Background: Trauma-related intrusive memories (TR-IMs) are core symptoms of posttraumatic stress disorder (PTSD). Prior research links reexperiencing symptoms with resting-state functional coupling between the right dorsolateral prefrontal cortex (dlPFC) and right hippocampus (HPC). However, prior work has not examined whether this negative coupling relates to TR-IMs or has differentiated between the anterior and posterior HPC (aHPC/pHPC). This study examined relationships of TR-IM frequency and properties with resting-state negative coupling between the right dlPFC and right aHPC/pHPC in symptomatic trauma-exposed individuals with TR-IMs.

Methods: Participants (N = 109; 88 female) completed 2 weeks of ecological momentary assessments capturing TR-IM frequency and properties (intrusiveness, emotional intensity, vividness, visual properties, and reliving). Using resting-state functional magnetic resonance imaging, participant-specific 4-mm spheres were placed at the right dlPFC voxel most anticorrelated with the right aHPC/pHPC. Quasi-Poisson and linear mixed-effect models assessed relationships of TR-IM frequency and properties with right dlPFC-right aHPC/pHPC anticorrelation.

Results: TR-IM emotional intensity was positively associated with right dlPFC-aHPC connectivity, while vividness and visual properties correlated with right dlPFC-pHPC connectivity. These associations remained significant after controlling for PTSD symptom severity and time since trauma. No significant associations emerged between TR-IM frequency, intrusiveness, or reliving and anticorrelation with either hippocampal subregion.

Conclusions: This study provides novel insights into the neural correlates of TR-IMs, highlighting the relevance of intrinsic negative coupling between the right dlPFC and aHPC/pHPC to their phenomenology. Further research on this circuit could advance understanding of component processes of trauma reexperiencing, a severe and treatment-refractory PTSD symptom.

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