纳米和脂质体癌症化疗:药物传递与应用进展综述。

IF 0.9 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Lianmei Zhang, Xinglin Jin
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引用次数: 0

摘要

恶性肿瘤的高发病率继续对公众健康构成重大威胁。近年来,肿瘤的治疗方法有了显著的进步,导致治疗观念和临床方法发生了实质性的变化。目前临床治疗恶性肿瘤的主要方法包括手术切除、放射治疗和化疗。其中,化疗是最关键、最全面的治疗策略之一。纳米科学的快速发展促进了纳米载体化合物的发展及其在疾病治疗中的临床应用。值得注意的是,纳米药物,包括戈舍雷林缓释植入物、阿霉素脂质体、白蛋白结合紫杉醇和紫杉醇脂质体,已在中国的肿瘤治疗中得到有效利用[10]。本文介绍了利用各种纳米载体进行肿瘤联合治疗的最新进展。并探讨了药物传递载体的临床应用和疗效。开发高效安全的共给药系统,促进药物在癌组织内的有效运输和精确释放,同时阐明纳米颗粒进入肿瘤细胞的内化及其功能机制,是未来研究的关键领域。同时,纳米载体和肿瘤治疗的进步有望带来更好的治疗效果,改善癌症患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nano and liposome cancer chemotherapy: A review of advances in drug delivery with applications.

The high incidence of malignant tumors continues to pose a significant threat to public health. In recent years, there have been notable advancements in tumor treatment methods, leading to substantial changes in the concepts and clinical approaches to treatment. The primary clinical methods for treating malignant tumors currently include surgical resection, radiation therapy, and chemotherapy. Among these, chemotherapy is one of the most crucial and comprehensive treatment strategies. The rapid progress in nanoscience has fostered the development of nanocarrier compounds and their clinical applications in disease treatment. Notably, nanomedicines, including goserelin sustained-release implants, doxorubicin liposomes, albumin-bound paclitaxel, and paclitaxel liposomes, have been effectively utilized in tumor treatment in China [1]. The article presents a comprehensive overview of recent advancements in utilizing various nanocarriers for combination therapy in tumors. It also examines the clinical application and efficacy of drug delivery carriers. The development of efficient and safe co-delivery systems that facilitate the effective transport and precise release of drugs within the cancerous tissues while also elucidating the internalization of nanoparticles into tumor cells and their functional mechanisms represents critical areas for future research. Concurrently, advancements in nanocarriers and tumor treatment are anticipated to yield superior therapeutic outcomes and improved quality of life for cancer patients.

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来源期刊
CiteScore
1.70
自引率
12.50%
发文量
116
审稿时长
4-8 weeks
期刊介绍: The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.
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