LI-RADS用于SonoVue和sonazoids对比增强超声诊断肝细胞癌的单中心前瞻性研究。

IF 2.2 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chen Lin, Xiao-huan Yang, Hong-yan Zhai, Xin-yuan Zhu, Gui-ming Zhou
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引用次数: 0

摘要

目的:比较两种HCC诊断算法的诊断性能:基于CEUS LI-RADS版本2017的SonoVue-CEUS和基于Kupffer-phase结果的Sonazoid-CEUS的改进算法。方法:这项单中心前瞻性研究纳入高危HCC患者。每位参与者分别行索诺维-超声心动图和索那唑-超声心动图。每个肝脏观察者根据每个算法分配两个LI-RADS类别:SonoVue-CEUS LI-RADS和改良Sonazoid-CEUS LI-RADS。对于后一种方法,观察到至少10mm的非边缘动脉期高强化,如果没有出现Kupffer缺陷的冲洗,则将LR-4升级为LR-5,如果出现轻度Kupffer缺陷的早期冲洗,则将LR-M重新分配为LR-5。参照标准为病理证实。结果:66例患者(平均年龄61.2岁±10.9岁;最终纳入54例男性患者,12例女性患者,66个观察值(平均尺寸,31 mm±16)。Sonazoid-CEUS LI-RADS的结果在灵敏度上有显著的变化(82% vs. 65%)。结论:与SonoVue-CEUS LI-RADS相比,Sonazoid-CEUS LI-RADS在合并kupoffer -phase结果时具有更高的灵敏度而不丧失特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LI-RADS for diagnosing hepatocellular carcinoma by contrast-enhanced US with SonoVue and Sonazoid—a single center prospective study

Purpose

To compare the diagnostic performance of two algorithms for HCC diagnosis: SonoVue-CEUS based on CEUS LI-RADS version 2017 and a modified algorithm incorporating Kupffer-phase findings for Sonazoid-CEUS.

Methods

This single center prospective study enrolled high-risk patients for HCC. Each participant underwent SonoVue-CEUS and Sonazoid-CEUS. Each liver observation was assigned two LI-RADS categories according to each algorithm: SonoVue-CEUS LI-RADS and modified Sonazoid-CEUS LI-RADS. For the latter method, observations at least 10 mm with non-rim arterial phase hyperenhancement were upgraded LR-4 to LR-5 if there was no washout with a Kupffer defect and were reassigned LR-M to LR-5 if there was early washout with mild Kupffer defect. The reference standard was pathologic confirmation.

Results

Overall, 66 patients (mean age, 61.2 years ± 10.9; 54 male patients, 12 female patients) with 66 observations (mean size, 31 mm ± 16) were eventually enrolled. The results of Sonazoid-CEUS LI-RADS showed significant changes in sensitivity (82% vs. 65%, p < 0.001), accuracy (85% vs. 71%, p < 0.001) compared with the SonoVue-CEUS LI-RADS. There was no significant difference in specificity (93% vs. 87%, p = 0.26).

Conclusion

When incorporating Kupffer-phase findings, Sonazoid-CEUS LI-RADS had higher sensitivity without loss of specificity compared with SonoVue-CEUS LI-RADS.

Graphical abstract

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来源期刊
Abdominal Radiology
Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.20
自引率
8.30%
发文量
334
期刊介绍: Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits
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