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IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-03-21 DOI:10.1016/j.envint.2025.109403

Huyen Nguyen Thi Khanh , Massimo Stafoggia , Mette Sørensen , Aslak Harbo Poulsen , Ole Raaschou-Nielsen , Jibran Khan , Jørgen Brandt , Anja Olsen , Zorana Jovanovic Andersen , Mette Kildevaeld Simonsen , Youn-Hee Lim , Jiawei Zhang , Thomas Cole-Hunter , Göran Pershagen , Andrei Pyko , Agneta Åkesson , Leonard Stockfelt , Eva M. Andersson , Mikael Ögren , David Segersson , Jeroen de Bont

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引用次数: 0

摘要

引言环境空气污染和道路交通噪声是中风的危险因素，但有关它们潜在联合效应的证据仍然有限。本研究使用乘法和加法尺度调查了空气污染和道路交通噪声对中风发病率的独立和联合影响。我们对住宅地址的室外颗粒物 < 2.5 µm (PM2.5)、二氧化氮 (NO2) 和道路交通噪声的年平均水平进行了模拟。我们采用 Cox 比例危险回归来评估它们之间的单一关联。我们在 Cox 模型中使用交互项评估了乘法交互作用，并使用交互作用导致的相对超额风险法评估了加法交互作用。在单一暴露模型中，PM2.5、二氧化氮和道路交通噪声与较高的中风风险相关。乘法模型显示，噪音水平越高，PM2.5 与中风之间的 HR 值越高，反之亦然：PM2.5 每 5 μg/m3 的 HR 值在 40 dB 时为 1.06（95 % CI：0.94-1.21），在 80 dB 时为 1.11（95 % CI：0.道路交通噪声为 80 dB 时，HRs 为 1.06（95 % CI：0.94-1.21）；道路交通噪声为 80 dB 时，HRs 为 1.11（95 % CI：0.85-1.44）；道路交通噪声为 4 μg/m3 时，HRs 为 1.06（95 % CI：1.01-1.11）；PM2.5 为 48 μg/m3 时，HRs 为 1.17（95 % CI：0.82-1.68）。相加模型显示，PM2.5 和道路交通噪声的综合相关性比其单独相关性的总和高 4% (RERI = 0.04 (95 % CI:-0.05; 1.12))。

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Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts

Introduction

Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales.

Methods

We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finland. We modelled annual average levels of outdoor particulate matter < 2.5 µm (PM_2.5), nitrogen dioxide (NO₂) and road traffic noise at residential addresses. We applied Cox proportional hazards regression to evaluate their single association. We assessed multiplicative interaction with interaction terms in Cox models and additive interaction using the Relative Excess Risk due to Interaction method.

Results

We followed 136,897 adults for 20 years, and 8.0 % experienced stroke incidence. PM_2.5, NO₂ and road traffic noise were associated with higher stroke risk in single-exposure models. Multiplicative models showed higher HRs between PM_2.5 and stroke at higher levels of noise and vice versa: HRs per 5 μg/m³ of PM_2.5 were 1.06 (95 % CI:0.94–1.21) at 40 dB and 1.11 (95 % CI:0.85–1.44) at 80 dB of road traffic noise; HRs per 12 dB of road traffic noise were 1.06 (95 % CI:1.01–1.11) at 4 μg/m³ and 1.17 (95 % CI:0.82–1.68) at 48 μg/m³ of PM_2.5. Additive models showed that the combined association of PM_2.5 and road traffic noise was 4 % (RERI = 0.04 (95 % CI:-0.05;1.12)) higher than the sum of their individual association.

Conclusion

PM_2.5 and road traffic noise showed a non-significant synergistic association on stroke incidence.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.