在杜匹单抗治疗后，一名有特应性皮炎病史的患者出现蕈样真菌病。高通量超声监测皮肤特征的有效性。一份带有病例报告的评论。

IF 1.4 4区医学 Q3 ALLERGY

Postepy Dermatologii I Alergologii Pub Date : 2025-02-01 Epub Date: 2024-09-25 DOI:10.5114/ada.2024.143463

Hanna Cisoń, Wiktor Cisoń, Barbara Białynicka-Birula, Marianna Suseł, Rafał Białynicki-Birula, Jacek C Szepietowski

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引用次数: 0

摘要

Dupilumab已经彻底改变了特应性皮炎（AD）的治疗，但人们担心它与皮肤t细胞淋巴瘤（CTCL）的潜在联系。本文综述了AD患者dupilumab治疗后CTCL的发生及其潜在的治疗效果。一项76岁严重AD患者接受dupilumab治疗的病例研究强调了了解dupilumab安全使用的相关机制和危险因素的必要性，该患者发展为显示蕈样真菌病（MF）的红皮病。这个病例也强调了高频超声在监测MF患者皮肤表现方面的应用。

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Mycosis fungoides unveiled following dupilumab treatment in a patient with a history of atopic dermatitis. Usefulness of HFUS in monitoring skin features. A review with a case report.

Dupilumab has revolutionized atopic dermatitis (AD) treatment, but concerns arise about its potential link to cutaneous T-cell lymphomas (CTCL). This review explores CTCL occurrence post-dupilumab therapy in AD and its potential therapeutic effects. A case study of a 76-year-old patient with severe AD treated with dupilumab, developing erythroderma revealing mycosis fungoides (MF), underscores the need to understand associated mechanisms and risk factors for safe dupilumab use. This case also highlights the utility of the high-frequency ultrasound in monitoring cutaneous manifestations in patients with MF.

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