{"title":"甘油三酯葡萄糖相关参数与肾结石的关联：NHANES 2007-2020的横断面研究","authors":"Hao Yu, Jian Wu","doi":"10.21037/tau-24-516","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index, combined with obesity-related indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), has been proven to be reliable for assessing insulin resistance (IR). The objective of this study is to investigate the relationships between TyG-related parameters and the prevalence of kidney stones among adults in the United States (US).</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2020 to evaluate the associations of TyG-related parameters with kidney stones. Weighted logistic regression, restricted cubic spline (RCS) analysis, receiver operating characteristic (ROC) analysis, and subgroup analysis were employed to investigate these relationships.</p><p><strong>Results: </strong>A total of 15,590 participants were included in the analysis. Significant differences were observed in the distributions of TyG-related parameters between those with and without kidney stones. In the fully adjusted model, participants in the highest quartile of TyG-related parameters had a higher risk of kidney stones compared to those in the lowest quartile [TyG-WC: odds ratio (OR): 2.08, 95% confidence interval (CI): 1.66-2.60; TyG-BMI: OR: 2.03, 95% CI: 1.61-2.57; TyG-WHtR: OR: 2.21, 95% CI: 1.72-2.84]. RCS analysis indicated that these associations were non-linear (P for nonlinearity <0.05). ROC analysis showed that TyG-WC had the highest diagnostic accuracy (area under curve: 0.6130). Subgroup analysis further revealed a stronger positive association between TyG-WC and TyG-WHtR and the prevalence of kidney stones in participants without hypertension (P for interaction <0.05).</p><p><strong>Conclusions: </strong>Taken together, there are strong positive correlations between TyG-related parameters and the prevalence of kidney stones in US adults. Our findings suggest that managing IR and preventing obesity may help reduce the risk of kidney stone formation.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 2","pages":"379-388"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921200/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations of triglyceride glucose-related parameters with kidney stones: a cross-sectional study from NHANES 2007-2020.\",\"authors\":\"Hao Yu, Jian Wu\",\"doi\":\"10.21037/tau-24-516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index, combined with obesity-related indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), has been proven to be reliable for assessing insulin resistance (IR). The objective of this study is to investigate the relationships between TyG-related parameters and the prevalence of kidney stones among adults in the United States (US).</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2020 to evaluate the associations of TyG-related parameters with kidney stones. Weighted logistic regression, restricted cubic spline (RCS) analysis, receiver operating characteristic (ROC) analysis, and subgroup analysis were employed to investigate these relationships.</p><p><strong>Results: </strong>A total of 15,590 participants were included in the analysis. Significant differences were observed in the distributions of TyG-related parameters between those with and without kidney stones. In the fully adjusted model, participants in the highest quartile of TyG-related parameters had a higher risk of kidney stones compared to those in the lowest quartile [TyG-WC: odds ratio (OR): 2.08, 95% confidence interval (CI): 1.66-2.60; TyG-BMI: OR: 2.03, 95% CI: 1.61-2.57; TyG-WHtR: OR: 2.21, 95% CI: 1.72-2.84]. RCS analysis indicated that these associations were non-linear (P for nonlinearity <0.05). ROC analysis showed that TyG-WC had the highest diagnostic accuracy (area under curve: 0.6130). Subgroup analysis further revealed a stronger positive association between TyG-WC and TyG-WHtR and the prevalence of kidney stones in participants without hypertension (P for interaction <0.05).</p><p><strong>Conclusions: </strong>Taken together, there are strong positive correlations between TyG-related parameters and the prevalence of kidney stones in US adults. Our findings suggest that managing IR and preventing obesity may help reduce the risk of kidney stone formation.</p>\",\"PeriodicalId\":23270,\"journal\":{\"name\":\"Translational andrology and urology\",\"volume\":\"14 2\",\"pages\":\"379-388\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921200/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational andrology and urology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tau-24-516\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ANDROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational andrology and urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tau-24-516","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ANDROLOGY","Score":null,"Total":0}
Associations of triglyceride glucose-related parameters with kidney stones: a cross-sectional study from NHANES 2007-2020.
Background: The triglyceride-glucose (TyG) index, combined with obesity-related indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), has been proven to be reliable for assessing insulin resistance (IR). The objective of this study is to investigate the relationships between TyG-related parameters and the prevalence of kidney stones among adults in the United States (US).
Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2020 to evaluate the associations of TyG-related parameters with kidney stones. Weighted logistic regression, restricted cubic spline (RCS) analysis, receiver operating characteristic (ROC) analysis, and subgroup analysis were employed to investigate these relationships.
Results: A total of 15,590 participants were included in the analysis. Significant differences were observed in the distributions of TyG-related parameters between those with and without kidney stones. In the fully adjusted model, participants in the highest quartile of TyG-related parameters had a higher risk of kidney stones compared to those in the lowest quartile [TyG-WC: odds ratio (OR): 2.08, 95% confidence interval (CI): 1.66-2.60; TyG-BMI: OR: 2.03, 95% CI: 1.61-2.57; TyG-WHtR: OR: 2.21, 95% CI: 1.72-2.84]. RCS analysis indicated that these associations were non-linear (P for nonlinearity <0.05). ROC analysis showed that TyG-WC had the highest diagnostic accuracy (area under curve: 0.6130). Subgroup analysis further revealed a stronger positive association between TyG-WC and TyG-WHtR and the prevalence of kidney stones in participants without hypertension (P for interaction <0.05).
Conclusions: Taken together, there are strong positive correlations between TyG-related parameters and the prevalence of kidney stones in US adults. Our findings suggest that managing IR and preventing obesity may help reduce the risk of kidney stone formation.
期刊介绍：
ranslational Andrology and Urology (Print ISSN 2223-4683; Online ISSN 2223-4691; Transl Androl Urol; TAU) is an open access, peer-reviewed, bi-monthly journal (quarterly published from Mar.2012 - Dec. 2014). The main focus of the journal is to describe new findings in the field of translational research of Andrology and Urology, provides current and practical information on basic research and clinical investigations of Andrology and Urology. Specific areas of interest include, but not limited to, molecular study, pathology, biology and technical advances related to andrology and urology. Topics cover range from evaluation, prevention, diagnosis, therapy, prognosis, rehabilitation and future challenges to urology and andrology. Contributions pertinent to urology and andrology are also included from related fields such as public health, basic sciences, education, sociology, and nursing.
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