肠道菌群在结直肠癌发病机制及预防中的研究进展（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI:10.3892/mmr.2025.13498

Weitong Sun, Shize Ma, Dongdong Meng, Chaoxing Wang, Jinbo Zhang

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引用次数: 0

摘要

肠道微生物群代表了一个多样化的群体，在结直肠癌（CRC）及其治疗结果中起着关键作用。测序技术的进步揭示了CRC患者中微生物组成和多样性的显著变化。同时，动物模型已经阐明了特定微生物如脆弱乳杆菌、大肠杆菌和核梭杆菌参与CRC的进展。本综述旨在强调肠道微生物群在结直肠癌发病机制中的作用，传统治疗方法对肠道微生物群的影响以及微生物群调节作为结直肠癌治疗策略的潜力。

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Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review).

The intestinal microbiota represents a diverse population that serves a key role in colorectal cancer (CRC) and its treatment outcomes. Advancements in sequencing have revealed notable shifts in microbial composition and diversity among individuals with CRC. Concurrently, animal models have elucidated the involvement of specific microbes such as Lactobacillus fragilis, Escherichia coli and Fusobacterium nucleatum in the progression of CRC. The present review aimed to highlight contributions of intestinal microbiota to the pathogenesis of CRC, the effects of traditional treatments on intestinal microbiota and the potential for microbiota modulation as a therapeutic strategy for CRC.

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来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.