混乱中的平静：靶向mTOR减少胶质瘤驱动的神经元过度兴奋性。

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-03-19 DOI:10.1016/j.neuron.2025.02.020

Matthia A Karreman, Varun Venkataramani

引用次数: 0

摘要

原发性脑肿瘤可诱导神经元亢奋，导致癫痫发作。在本期《神经元》杂志上，Goldberg等人1在小鼠模型中展示了兴奋性肿瘤相关神经元的遗传、结构和功能改变，以及mTOR抑制如何快速逆转这些变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Calm in the chaos: Targeting mTOR to reduce glioma-driven neuronal hyperexcitability.

Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.¹ demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.