与平时的摄入量相比,ke 可改善心血管代谢疾病风险增加的成年人的脂蛋白颗粒浓度:随机对照试验》。

IF 3.7 3区 医学 Q2 NUTRITION & DIETETICS
Tricia L Hart, Penny M Kris-Etherton, Kristina S Petersen
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引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
ke Improves Lipoprotein Particle Concentrations Compared to Usual Intake in Adults at Increased Risk for Cardiometabolic Diseases: A Randomized Controlled Trial.

Background: Pecan consumption consistently improves lipoproteins, but less research has investigated the effect of pecans on lipoprotein subfractions.

Objectives: The aim was to investigate the effect of substitution of usual snack foods with 57 g/day of pecans on lipoprotein particle subfractions and apolipoproteins compared to continuing usual intake after 12 weeks. Exploratory analyses evaluated effects on early markers of insulin resistance including the Lipoprotein Insulin Resistance Index (LP-IR), Diabetes Risk Index (DRI), and GlycA.

Methods: A 12-week, randomized, 2-armed parallel trial in adults at risk for cardiometabolic disease was conducted. Participants were instructed to either consume 57 g/day of pecans in place of usual snacks or to continue usual intake. Plasma samples collected at baseline and 12 weeks were analyzed for lipoproteins, apolipoproteins and GlycA by proton nuclear magnetic resonance spectroscopy. Between-group differences in the change from baseline were evaluated with linear regression.

Results: In total, 138 participants were randomized (n=69 per group) and 130 participants (pecan group n=62; usual diet group n=68) completed the trial. The pecan group had a greater reduction from baseline in the concentrations of apolipoprotein B (apoB) (-4.38 mg/dL; 95%CI -8.02, -0.73), total LDL (-75.3 nmol/L; 95%CI -144, -6.93), total triglyceride rich lipoproteins (TRL-P) (-20.4 nmol/L; 95%CI -33.8, -7.03), large (-1.47 nmol/L; 95%CI -2.69, -0.26) and small (-11.3 nmol/L; 95%CI -22.4, -0.27) TRL-P and the LP-IR (-4.42 points; 95%CI -8.14, -0.69), and greater increases from baseline in the concentration of large high density lipoproteins (0.35 μmol/L; 95%CI 0.07, 0.63) compared to the usual diet group.

Conclusions: Incorporating 57 g/day of pecans into the diet in place of usual snacks for 12 weeks improved apoB, atherogenic lipoprotein subfractions, and the LP-IR in adults at risk for cardiometabolic diseases.

Clinical trials registration: https://clinicaltrials.gov/study/NCT05071807; NCT05071807.

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来源期刊
Journal of Nutrition
Journal of Nutrition 医学-营养学
CiteScore
7.60
自引率
4.80%
发文量
260
审稿时长
39 days
期刊介绍: The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
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