解码阿尔茨海默病中的小胶质细胞功能:从人体模型中获得的启示。

IF 13.1 1区 医学 Q1 IMMUNOLOGY
Trends in Immunology Pub Date : 2025-04-01 Epub Date: 2025-03-19 DOI:10.1016/j.it.2025.02.011
Chandrika Rao, Stefan Semrau, Valentina Fossati
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引用次数: 0

摘要

小胶质细胞是大脑免疫反应的关键协调者,在阿尔茨海默病(AD)的进展中起着关键作用。新兴的人类模型,包括干细胞衍生的小胶质细胞和脑类器官,正在改变我们对小胶质细胞对阿尔茨海默病病理的理解。在这篇综述中,我们强调了这些模型如何揭示了人类特异性的小胶质细胞对淀粉样斑块的反应及其对神经炎症的调节,这在动物模型中没有得到概括。我们还说明了如何更好地模拟大脑生理和AD病理的先进人类模型为小胶质细胞的多方面作用提供了前所未有的见解。这些创新的方法,结合复杂的细胞编辑和分析技术,正在塑造阿尔茨海默病的研究,并为针对小胶质细胞的治疗干预开辟新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decoding microglial functions in Alzheimer's disease: insights from human models.

Microglia, key orchestrators of the brain's immune responses, play a pivotal role in the progression of Alzheimer's disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we highlight how these models have uncovered human-specific microglial responses to amyloid plaques and their regulation of neuroinflammation, which are not recapitulated in animal models. We also illustrate how advanced human models that better mimic brain physiology and AD pathology are providing unprecedented insights into the multifaceted roles of microglia. These innovative approaches, combined with sophisticated technologies for cell editing and analysis, are shaping AD research and opening new avenues for therapeutic interventions targeting microglia.

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来源期刊
Trends in Immunology
Trends in Immunology 医学-免疫学
CiteScore
25.10
自引率
0.60%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
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