体位对人脑心动周期动态表观扩散系数变化的影响

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Naoki Ohno, Tosiaki Miyati, Masatomo Uehara, Riho Okamoto, Mitsuhito Mase, Satoshi Kobayashi
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引用次数: 0

摘要

背景:心循环过程中表观扩散系数(ΔADC)的动态变化反映了脑内和颅内水分子的波动情况。虽然体位强烈影响颅内状况,但由于传统的MRI通常仅在仰卧位进行,因此对ΔADC与体位之间的关系探索较少。目的:利用多体位MRI系统研究仰卧位和坐位时大脑的ΔADC和平均ADC (ADCmean)。研究类型:前瞻性。受试者:9名健康志愿者(均为男性;平均年龄23.5岁)。场强/序列:0.4 T,心电图同步单次扩散回波平面成像序列,b值分别为0和500 s/mm2。评估:每个受试者在坐位和仰卧位的多个心脏阶段生成ADC图。对于每个位置,然后生成一个ADCmean地图作为所有阶段的体素平均ADC,并生成一个ΔADC地图作为各个阶段ADC的体素最大差异。分别测量2个额叶和2个枕叶区域的ΔADC和ADCmean并取平均值。比较仰卧位和坐位的ADCmean、ΔADC、心率(HR)。统计检验:Wilcoxon sign -rank检验。结果:坐位ΔADC和ADCmean均显著高于仰卧位(ΔADC: 0.84±0.06 × 10-3 mm2/s vs. 0.68±0.05 × 10-3 mm2/s;ADCmean: 0.87±0.02×三平方毫米/秒和0.79±0.06×三平方毫米/ s,分别)。这些增长在所有参与者中都是一致的。此外,坐姿的心率明显高于仰卧位(73.8±8.4 bpm比58.1±3.7 bpm)。数据结论:坐位时脑部的ΔADC和ADCmean明显高于仰卧位。证据等级:2。技术功效:第一阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Body Position on Dynamic Apparent Diffusion Coefficient Changes During the Cardiac Cycle in the Human Brain.

Background: Dynamic changes in the apparent diffusion coefficient (ΔADC) during the cardiac cycle reflect water molecule fluctuations in the brain and intracranial conditions. While body position strongly affects intracranial conditions, the relationship between ΔADC and body position has been less explored, as conventional MRI is typically performed only in the supine position.

Purpose: To investigate ΔADC and mean ADC (ADCmean) of the brain in supine and sitting positions using a multi-posture MRI system.

Study type: Prospective.

Subjects: Nine healthy volunteers (all males; mean age, 23.5 years).

Field strength/sequence: 0.4 T, electrocardiographically synchronized single-shot diffusion echo-planar imaging sequence with b-values of 0 and 500 s/mm2.

Assessment: ADC maps were generated at multiple cardiac phases in each subject in the sitting and supine positions. For each position, an ADCmean map was then generated as the voxel-wise mean ADC across all phases, and a ΔADC map was generated as the voxel-wise maximum difference in ADC across phases. ΔADC and ADCmean were measured in 2 frontal and 2 occipital lobe regions and averaged. ΔADC, ADCmean, and heart rate (HR) were compared between supine and sitting positions.

Statistical tests: Wilcoxon signed-rank test. Significance was set at p < 0.05.

Results: Both ΔADC and ADCmean were significantly higher in the sitting position compared with the supine position (ΔADC: 0.84 ± 0.06 × 10-3 mm2/s vs. 0.68 ± 0.05 × 10-3 mm2/s; ADCmean: 0.87 ± 0.02 × 10-3 mm2/s vs. 0.79 ± 0.06 × 10-3 mm2/s, respectively). These increases were consistent across all participants. In addition, HR was significantly higher in the sitting position compared with the supine position (73.8 ± 8.4 bpm vs. 58.1 ± 3.7 bpm).

Data conclusion: ΔADC and ADCmean of the brain are significantly higher in the sitting position than in the supine position.

Evidence level: 2. Technical Efficacy: Stage 1.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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