{"title":"基于sers的横向流动免疫层析技术在食品安全领域的发展与应用","authors":"Wenxi Liu, Hao Wang, Wenhui Zhong, Yichun Zhang, Yingyue Liu, Xibao Gao, Mengmeng Yan, Chao Zhu","doi":"10.1007/s00604-025-07047-7","DOIUrl":null,"url":null,"abstract":"<div><p>Surface-Enhanced Raman Scattering-Lateral Flow Immunoassay (SERS-LFIA) inherits the advantages of simplicity, rapidness, and stability from Lateral Flow Immunoassay (LFIA), while integrating the sensitivity and accuracy of SERS, thereby attracting extensive attention in the field of food safety monitoring. This paper delves into the design strategies and principles underlying SERS-LFIA, introducing the detection formats based on SERS and contrasting the differences between traditional Raman molecules and those located in the Raman-silent region. It analyzes two immunoassay methods, namely sandwich and competitive, along with their respective applications. Importantly, by reviewing the applications of SERS-LFIA in food safety monitoring over the past 5 years, this paper summarizes the challenges faced by SERS-LFIA technology in practical applications and development. Furthermore, it provides a forward-looking perspective on the future development of SERS-LFIA. As a pivotal analytical method in the field of food safety monitoring, SERS-LFIA is demonstrating immense potential. It is hoped that this paper will offer valuable insights for the future development and application of SERS-LFIA.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 4","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-025-07047-7.pdf","citationCount":"0","resultStr":"{\"title\":\"The development and application of SERS-based lateral flow immunochromatography in the field of food safety\",\"authors\":\"Wenxi Liu, Hao Wang, Wenhui Zhong, Yichun Zhang, Yingyue Liu, Xibao Gao, Mengmeng Yan, Chao Zhu\",\"doi\":\"10.1007/s00604-025-07047-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Surface-Enhanced Raman Scattering-Lateral Flow Immunoassay (SERS-LFIA) inherits the advantages of simplicity, rapidness, and stability from Lateral Flow Immunoassay (LFIA), while integrating the sensitivity and accuracy of SERS, thereby attracting extensive attention in the field of food safety monitoring. This paper delves into the design strategies and principles underlying SERS-LFIA, introducing the detection formats based on SERS and contrasting the differences between traditional Raman molecules and those located in the Raman-silent region. It analyzes two immunoassay methods, namely sandwich and competitive, along with their respective applications. Importantly, by reviewing the applications of SERS-LFIA in food safety monitoring over the past 5 years, this paper summarizes the challenges faced by SERS-LFIA technology in practical applications and development. Furthermore, it provides a forward-looking perspective on the future development of SERS-LFIA. As a pivotal analytical method in the field of food safety monitoring, SERS-LFIA is demonstrating immense potential. It is hoped that this paper will offer valuable insights for the future development and application of SERS-LFIA.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 4\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s00604-025-07047-7.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07047-7\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07047-7","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
The development and application of SERS-based lateral flow immunochromatography in the field of food safety
Surface-Enhanced Raman Scattering-Lateral Flow Immunoassay (SERS-LFIA) inherits the advantages of simplicity, rapidness, and stability from Lateral Flow Immunoassay (LFIA), while integrating the sensitivity and accuracy of SERS, thereby attracting extensive attention in the field of food safety monitoring. This paper delves into the design strategies and principles underlying SERS-LFIA, introducing the detection formats based on SERS and contrasting the differences between traditional Raman molecules and those located in the Raman-silent region. It analyzes two immunoassay methods, namely sandwich and competitive, along with their respective applications. Importantly, by reviewing the applications of SERS-LFIA in food safety monitoring over the past 5 years, this paper summarizes the challenges faced by SERS-LFIA technology in practical applications and development. Furthermore, it provides a forward-looking perspective on the future development of SERS-LFIA. As a pivotal analytical method in the field of food safety monitoring, SERS-LFIA is demonstrating immense potential. It is hoped that this paper will offer valuable insights for the future development and application of SERS-LFIA.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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