辐照诱导自由基继电法对苯乙烯1,2-酰基磷酸化获取β-芳基-γ-酮膦氧化物的研究

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-03-11 DOI:10.1021/acs.joc.4c0274910.1021/acs.joc.4c02749

Dengyu Yin, Lishuai Lu, Yandong Dou, Shihao Li, Ming-Chen Fu*, Yanwu Zhu* and Shilu Fan*,

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引用次数: 0

摘要

以苯乙烯和酰基唑盐为原料，通过辐照诱导自由基接力机制，设计了一种酰基膦化反应，合成了β-芳基-γ-酮膦氧化物。该方法有效地构建了C-C和C-P键，并表现出良好的官能团耐受性。机理研究表明，该反应涉及自由基-加成-偶联-消除级联过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay

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1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay

An acylphosphinylation reaction has been devised for the synthesis of β-aryl-γ-ketophosphine oxides, employing styrenes and acyl azolium salts through an irradiation-induced radical relay mechanism. This method effectively constructs C–C and C–P bonds while demonstrating excellent functional group tolerance. Mechanistic studies revealed that a radical-addition–coupling–elimination cascade process was involved in this reaction.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.