蓝光诱导 α-烷基化氨基酸衍生物的立体选择性合成

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-03-21 DOI:10.1002/ejoc.202401477

Hongying Fan, Meiling Ye, Xue Zhang, Jinyu Hou, Liulin Jiao, Jian Chen, Li Guo, Zhong Lian, Yong Wu

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引用次数: 0

摘要

以(+)/(-)-樟脑坦为手性助剂，以烷基 N-羟基邻苯二甲酰亚胺酯为自由基前体，采用光氧化催化法对甘氨酸衍生物进行脱羧 C(sp3)-H 烷基化反应，在温和条件下高效合成对映体富集的α-烷基化氨基酸衍生物，具有极佳的立体选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Blue-Light-Induced Stereoselective Synthesis of α-Alkylated Amino Acid Derivatives

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Blue-Light-Induced Stereoselective Synthesis of α-Alkylated Amino Acid Derivatives

A photoredox-catalyzed method for decarboxylative C(sp³)−H alkylation of glycine derivatives, using (+)/(−)-camphorsultam as a chiral auxiliary and alkyl N-hydroxyphthalimide ester as a radical precursor, which enables the efficient synthesis of enantioenriched α-alkylated amino acid derivatives under mild conditions with excellent stereoselectivity.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.