- Book学术

发布求助

文献互助智能选刊最新文献

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2025-04-01 DOI:10.1016/j.arcped.2024.11.010

Hanane Chettouh , Karima Haddad , Nafissa Mahieddine , Azzedine Mekki , Zoulikha Zeroual , Zouhir Berrou , Souhaila Rezzoug

{"title":"Subacute sclerosing panencephalitis: Disease profile in early childhood","authors":"Hanane Chettouh , Karima Haddad , Nafissa Mahieddine , Azzedine Mekki , Zoulikha Zeroual , Zouhir Berrou , Souhaila Rezzoug","doi":"10.1016/j.arcped.2024.11.010","DOIUrl":null,"url":null,"abstract":"<div><div>Subacute sclerosing panencephalitis (SSPE), a progressive inflammatory neurodegenerative disease of the central nervous system caused by the measles virus, is experiencing a significant resurgence following recent measles epidemics. This study aimed to investigate the pathology of SSPE in early childhood and determine its clinical, electrophysiological, and radiological characteristics.</div></div><div><h3>Materials and methods</h3><div>This retrospective, descriptive study was conducted at the Pediatric Department of Nafissa Hamoud University Hospital in Algiers. The study included children aged 2–6 years who were hospitalized for subacute neurological disorders. Data collection spanned a 3-year period from January 1, 2020, to December 31, 2022.</div></div><div><h3>Results and discussion</h3><div>A total of 47 patients were examined, comprising 37 boys and 10 girls. The average age was 45.9 months (range: 24–72 months). Notably, 41 (87 %) of the patients had not received measles vaccination, and 37 (80 %) had contracted the measles virus, with 31 cases (83.8 %) occurring in children under 1 year of age. SSPE manifested approximately 3 years after infection (range: 1–5 years). Clinical events primarily included myoclonic seizures (26 cases), tonic–clonic seizures (6 cases), atonic seizures (6 cases), and focal seizures (3 cases); movement disorders were observed in 25 patients, and cognitive decline in 28 patients. Encephalitis manifestations, such as alterations in consciousness or behavior and psychiatric symptoms, were frequently observed. Electroencephalograms (EEG) revealed characteristic periodic complexes in only 22 patients. Magnetic resonance imaging (MRI) scans were normal in 24 patients but showed characteristic anomalies in 21 patients, primarily consisting of white matter hyperintensity and cortico-subcortical atrophy.</div></div><div><h3>Conclusion</h3><div>SSPE is not rare in early childhood. The latency period between virus infection and disease onset can be very short. Clinical, electroencephalographic, and radiological signs of the disease in young children may be atypical. Genetic studies are necessary to establish a genetic predisposition to the disease. Measles vaccination remains the most effective preventive measure against SSPE.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 175-183"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives De Pediatrie","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0929693X25000533","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

摘要

亚急性硬化性泛脑炎（SSPE）是一种由麻疹病毒引起的中枢神经系统进行性炎症性神经退行性疾病，在最近的麻疹流行病疫情中再次出现。本研究旨在调查幼儿期 SSPE 的病理变化，并确定其临床、电生理学和放射学特征：这项回顾性、描述性研究在阿尔及尔纳菲萨-哈穆德大学医院儿科进行。研究对象包括因亚急性神经系统疾病住院的 2-6 岁儿童。数据收集时间为 2020 年 1 月 1 日至 2022 年 12 月 31 日，为期 3 年：共有 47 名患者接受了检查，其中包括 37 名男孩和 10 名女孩。平均年龄为 45.9 个月（范围：24-72 个月）。值得注意的是，41 名患者（87%）未接种过麻疹疫苗，37 名患者（80%）感染过麻疹病毒，其中 31 例（83.8%）发生在 1 岁以下的儿童身上。SSPE 约在感染后 3 年出现（范围：1-5 年）。临床症状主要包括肌阵挛发作（26 例）、强直阵挛发作（6 例）、失张力发作（6 例）和局灶性发作（3 例）；25 例患者出现运动障碍，28 例患者出现认知能力下降。意识或行为改变以及精神症状等脑炎表现也经常出现。只有 22 名患者的脑电图（EEG）显示出特征性的周期性复合体。24名患者的磁共振成像（MRI）扫描结果正常，但有21名患者出现特征性异常，主要包括白质高密度和皮质-皮质下萎缩：结论：SSPE 在幼儿期并不罕见。结论：SSPE 在儿童早期并不罕见，病毒感染与发病之间的潜伏期可能很短。幼儿的临床、脑电图和影像学表现可能不典型。有必要进行遗传学研究，以确定该病的遗传倾向。接种麻疹疫苗仍然是预防 SSPE 的最有效措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Subacute sclerosing panencephalitis: Disease profile in early childhood

Subacute sclerosing panencephalitis (SSPE), a progressive inflammatory neurodegenerative disease of the central nervous system caused by the measles virus, is experiencing a significant resurgence following recent measles epidemics. This study aimed to investigate the pathology of SSPE in early childhood and determine its clinical, electrophysiological, and radiological characteristics.

Materials and methods

This retrospective, descriptive study was conducted at the Pediatric Department of Nafissa Hamoud University Hospital in Algiers. The study included children aged 2–6 years who were hospitalized for subacute neurological disorders. Data collection spanned a 3-year period from January 1, 2020, to December 31, 2022.

Results and discussion

A total of 47 patients were examined, comprising 37 boys and 10 girls. The average age was 45.9 months (range: 24–72 months). Notably, 41 (87 %) of the patients had not received measles vaccination, and 37 (80 %) had contracted the measles virus, with 31 cases (83.8 %) occurring in children under 1 year of age. SSPE manifested approximately 3 years after infection (range: 1–5 years). Clinical events primarily included myoclonic seizures (26 cases), tonic–clonic seizures (6 cases), atonic seizures (6 cases), and focal seizures (3 cases); movement disorders were observed in 25 patients, and cognitive decline in 28 patients. Encephalitis manifestations, such as alterations in consciousness or behavior and psychiatric symptoms, were frequently observed. Electroencephalograms (EEG) revealed characteristic periodic complexes in only 22 patients. Magnetic resonance imaging (MRI) scans were normal in 24 patients but showed characteristic anomalies in 21 patients, primarily consisting of white matter hyperintensity and cortico-subcortical atrophy.

Conclusion

SSPE is not rare in early childhood. The latency period between virus infection and disease onset can be very short. Clinical, electroencephalographic, and radiological signs of the disease in young children may be atypical. Genetic studies are necessary to establish a genetic predisposition to the disease. Measles vaccination remains the most effective preventive measure against SSPE.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.