{"title":"在秀丽隐杆线虫中，Q神经母细胞左右不对称迁移需要在表皮胶原DPY-17和SQT-3中达成一致的蛋白切割位点。","authors":"Vedant D Jain, Celeste J Gormly, Erik A Lundquist","doi":"10.17912/micropub.biology.001526","DOIUrl":null,"url":null,"abstract":"<p><p>Previous studies showed that the apically secreted cuticular collagens DPY-17 , SQT-3 , and DPY-14 control the left-right asymmetric migration of the Q neuroblasts in <i>Caenorhabditis. elegans</i> . Furthermore, apical secretion of DPY-17 and SQT-3 require the BLI-4 proprotein convertase of the subtilisin/kexin family and the consensus furin cleavage site (CFCS) in the N-terminus of DPY-17 and SQT-3 . Work here shows that the CFCS sites of DPY-17 and SQT-3 are required for their roles in Q neuroblast migration. <i>bli-4</i> mutants had only weak effects on Q neuroblast migration, possibly due to redundancy among isoforms. These results suggest that apical secretion of cuticular collagens is required for Q neuroblast migration. These collagens might themselves provide left-right asymmetric guidance information, or might regulate another aspect of Q cell interaction with the cuticle, such as adhesion.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920829/pdf/","citationCount":"0","resultStr":"{\"title\":\"Consensus furin cleavage sites in the cuticular collagens DPY-17 and SQT-3 are required for Q neuroblast left-right asymmetric migration in <i>Caenorhabditis elegans</i>.\",\"authors\":\"Vedant D Jain, Celeste J Gormly, Erik A Lundquist\",\"doi\":\"10.17912/micropub.biology.001526\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Previous studies showed that the apically secreted cuticular collagens DPY-17 , SQT-3 , and DPY-14 control the left-right asymmetric migration of the Q neuroblasts in <i>Caenorhabditis. elegans</i> . Furthermore, apical secretion of DPY-17 and SQT-3 require the BLI-4 proprotein convertase of the subtilisin/kexin family and the consensus furin cleavage site (CFCS) in the N-terminus of DPY-17 and SQT-3 . Work here shows that the CFCS sites of DPY-17 and SQT-3 are required for their roles in Q neuroblast migration. <i>bli-4</i> mutants had only weak effects on Q neuroblast migration, possibly due to redundancy among isoforms. These results suggest that apical secretion of cuticular collagens is required for Q neuroblast migration. These collagens might themselves provide left-right asymmetric guidance information, or might regulate another aspect of Q cell interaction with the cuticle, such as adhesion.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920829/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001526\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Consensus furin cleavage sites in the cuticular collagens DPY-17 and SQT-3 are required for Q neuroblast left-right asymmetric migration in Caenorhabditis elegans.
Previous studies showed that the apically secreted cuticular collagens DPY-17 , SQT-3 , and DPY-14 control the left-right asymmetric migration of the Q neuroblasts in Caenorhabditis. elegans . Furthermore, apical secretion of DPY-17 and SQT-3 require the BLI-4 proprotein convertase of the subtilisin/kexin family and the consensus furin cleavage site (CFCS) in the N-terminus of DPY-17 and SQT-3 . Work here shows that the CFCS sites of DPY-17 and SQT-3 are required for their roles in Q neuroblast migration. bli-4 mutants had only weak effects on Q neuroblast migration, possibly due to redundancy among isoforms. These results suggest that apical secretion of cuticular collagens is required for Q neuroblast migration. These collagens might themselves provide left-right asymmetric guidance information, or might regulate another aspect of Q cell interaction with the cuticle, such as adhesion.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
