通过血液黏度、红细胞变形性和聚集性对甲亢患者血液流变学的研究。

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Sena Ebru Caglar, Yunus Karakoc, Alpaslan Tanoglu, Refik Demirtunc, Seher Tanrikulu, Hande Kilickaya, Muhterem Ercan
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引用次数: 0

摘要

目的:甲亢对心血管、造血系统和代谢的影响可能导致血液流变学的改变。本研究旨在探讨甲状腺机能亢进患者血液流变学特性的变化,包括红细胞变形性和聚集性、全血粘度(WBV)和血浆粘度(PV)。研究了抗甲状腺治疗对血液流变学的影响。材料方法:36例显性甲状腺功能亢进患者、19例亚临床甲状腺功能亢进患者和66例对照组纳入研究。治疗前测定红细胞压积、红细胞变形性和聚集性、血浆和全血粘度值。将患者血液流变学指标与对照组进行比较。分析显性甲状腺功能亢进患者治疗前后的结果。甲巯咪唑作为抗甲状腺治疗。可变形性和聚集性测量使用激光测速仪(LORRCA)进行,粘度测量使用锥板粘度计(Brookfield DV-III)进行。结果:最大伸长率(EImax)由处理前的0.664(0.01)降至处理后的0.657(0.01),差异有统计学意义(p = 0.04)。亚临床甲状腺功能亢进组[68.05 (7.66),p = 0.001]和显性甲状腺功能亢进组[66.78 (8.815),p = 0.001]的聚集指数均显著高于对照组。此外,亚临床甲状腺功能亢进组和显性甲状腺功能亢进组的聚集半衰期分别为1.9(1.21-2.27)和1.91 (1.43-2.46),p = 0.001,显著短于对照组。结论:甲状腺激素过量对亚临床和显性甲亢患者血液流变学状况均有影响。此外,甲巯咪唑抗甲状腺治疗可能在治疗后观察到的最大延伸指数下降中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of hemorheology in patients with hyperthyroidism via blood viscosity, erythrocyte deformability and aggregation.

Objective: Hyperthyroidism's impact on cardiovascular, hematopoietic systems and metabolism might lead to hemorheological changes. This study aimed to investigate the changes in hemorheological properties via erythrocyte deformability and aggregation, whole blood viscosity (WBV) and plasma viscosity (PV) in hyperthyroid patients. The effect of anti-thyroid treatment on hemorheology was also studied. MATERIAL METHODS: Thirty-six patients with overt hyperthyroidism, 19 patients with subclinical hyperthyroidism and 66 controls were included in the study. Hematocrit, erythrocyte deformability and aggregation, plasma and whole blood viscosity values were measured before treatment. Hemorheological parameters of the patients were compared with the control. Before and after treatment results of overt hyperthyroidism were analyzed. Methimazole was given as anti-thyroid treatment. Deformability and aggregation measurements were conducted using a laser ektacytometer (LORRCA) while viscosity measurements were performed with a cone-plate viscometer (Brookfield DV-III).

Results: The maximum elongation index (EImax) decreased significantly from 0.664 (0.01) pre-treatment to 0.657 (0.01) post-treatment (p = 0.04). The aggregation index was significantly higher in both the subclinical hyperthyroidism group [68.05 (7.66), p = 0.001] and the overt hyperthyroidism group [66.78 (8.815), p = 0.001] compared to the control group. Additionally, the aggregation half-time was significantly shorter in the subclinical hyperthyroidism group [1.9 (1.21-2.27), p = 0.001] and the overt hyperthyroidism group [1.91 (1.43-2.46), p = 0.001] relative to the control group.

Conclusion: The hemorheological status of patients was influenced by excessive thyroid hormones in both subclinical and overt hyperthyroidism groups. Additionally, anti-thyroid therapy with methimazole may play a role in the observed decrease in the maximum elongation index following treatment.

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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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