Sarah K Abe, Manami Inoue, Nobufumi Yasuda, Kazumasa Yamagishi, Shoichiro Tsugane, Norie Sawada
{"title":"日本多不饱和脂肪酸、鱼类摄入量和致残性痴呆风险：JPHC致残性痴呆研究。","authors":"Sarah K Abe, Manami Inoue, Nobufumi Yasuda, Kazumasa Yamagishi, Shoichiro Tsugane, Norie Sawada","doi":"10.1017/S1368980025000308","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the association between fish intake, <i>n</i>-3 PUFA, <i>n</i>-6 PUFA and risk of disabling dementia.</p><p><strong>Design: </strong>Prospective cohort.</p><p><strong>Setting: </strong>Municipalities within the Japan Public Health Centre-based Prospective Study.</p><p><strong>Participants: </strong>43 651 participants: (20 002 men and 23 649 women).</p><p><strong>Results: </strong>Exposure intake of fish, <i>n</i>-3 and <i>n</i>-6 PUFA was evaluated in 1995-1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006-2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0-IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, <i>n</i>-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (<i>P</i> for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (<i>P</i> for trend = 0·043).</p><p><strong>Conclusions: </strong>Our findings suggest no association with fish in general and only <i>n</i>-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women.</p>","PeriodicalId":20951,"journal":{"name":"Public Health Nutrition","volume":" ","pages":"e65"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086724/pdf/","citationCount":"0","resultStr":"{\"title\":\"PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study.\",\"authors\":\"Sarah K Abe, Manami Inoue, Nobufumi Yasuda, Kazumasa Yamagishi, Shoichiro Tsugane, Norie Sawada\",\"doi\":\"10.1017/S1368980025000308\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of this study was to assess the association between fish intake, <i>n</i>-3 PUFA, <i>n</i>-6 PUFA and risk of disabling dementia.</p><p><strong>Design: </strong>Prospective cohort.</p><p><strong>Setting: </strong>Municipalities within the Japan Public Health Centre-based Prospective Study.</p><p><strong>Participants: </strong>43 651 participants: (20 002 men and 23 649 women).</p><p><strong>Results: </strong>Exposure intake of fish, <i>n</i>-3 and <i>n</i>-6 PUFA was evaluated in 1995-1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006-2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0-IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, <i>n</i>-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (<i>P</i> for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (<i>P</i> for trend = 0·043).</p><p><strong>Conclusions: </strong>Our findings suggest no association with fish in general and only <i>n</i>-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women.</p>\",\"PeriodicalId\":20951,\"journal\":{\"name\":\"Public Health Nutrition\",\"volume\":\" \",\"pages\":\"e65\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086724/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Public Health Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S1368980025000308\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S1368980025000308","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study.
Objective: The aim of this study was to assess the association between fish intake, n-3 PUFA, n-6 PUFA and risk of disabling dementia.
Design: Prospective cohort.
Setting: Municipalities within the Japan Public Health Centre-based Prospective Study.
Participants: 43 651 participants: (20 002 men and 23 649 women).
Results: Exposure intake of fish, n-3 and n-6 PUFA was evaluated in 1995-1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006-2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0-IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, n-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (P for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (P for trend = 0·043).
Conclusions: Our findings suggest no association with fish in general and only n-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women.
期刊介绍：
Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.
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