Chongjie Yao, Yuchen Zhang, Sizheng Steven Zhao, Jun Ren, Pingping Sun, Lingjun Kong, Jiming Tao, Jingxian Li, Min Fang, Qingguang Zhu
{"title":"体育活动对慢性广泛性疼痛的影响：来自荟萃分析和双样本孟德尔随机化的见解。","authors":"Chongjie Yao, Yuchen Zhang, Sizheng Steven Zhao, Jun Ren, Pingping Sun, Lingjun Kong, Jiming Tao, Jingxian Li, Min Fang, Qingguang Zhu","doi":"10.2147/JPR.S505397","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic widespread pain (CWP) is a core symptom of fibromyalgia that is associated with significant morbidity and mortality. Despite the widespread recommendation for physical activity (PA) in management, the heterogeneity of PA prescriptions limits the in-depth evaluation of its efficacy. By triangulating clinical interventional evidence with human genetic evidence, the aim of this study was to investigate the role of influencing factors such as PA mode, course of treatment, and intensity on PA in the prevention and treatment of CWP.</p><p><strong>Methods: </strong>Ten international and regional databases were searched for articles published between January 2014 and July 2024. Randomized control trials with CWP or fibromyalgia as an entry criterion and PA as an intervention were included. Meta-analyses were performed using fixed- or random-effects models based on heterogeneity, and subgroup analyses were conducted. Mendelian randomization (MR) was used to estimate the effects of the genetic variants linked to PA intensity on CWP risk.</p><p><strong>Results: </strong>The analysis included 11 studies with 540 participants. PA effectively improved pain perception (MD: -1.47; 95% CI: -2.23, -0.72), depression (MD: -4.77; 95% CI: -7.40, -2.14), and overall quality of life (SMD: -1.43; 95% CI: -2.16, -0.69). MR analysis revealed that several PA intensities were associated with reduced susceptibility to CWP: walking for pleasure (OR: 0.950; 95% CI: 0.934-0.966), light do-it-yourself (DIY) (OR: 0.976; 95% CI: 0.961-0.992), strenuous sports (OR: 0.923; 95% CI: 0.880-0.967), and other exercises (OR: 0.957; 95% CI: 0.942-0.973).</p><p><strong>Conclusion: </strong>PA interventions are beneficial for reducing pain perception and mood disorders and enhancing the quality of life of patients with CWP. A treatment course of approximately three months is preferable, with Ba-Duan-Jin potentially more effective than other PAs, and high-intensity PA offers the most significant protective effect against CWP.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1275-1289"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920634/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of Physical Activity on Chronic Widespread Pain: Insights From Meta-Analysis and Two-Sample Mendelian Randomization.\",\"authors\":\"Chongjie Yao, Yuchen Zhang, Sizheng Steven Zhao, Jun Ren, Pingping Sun, Lingjun Kong, Jiming Tao, Jingxian Li, Min Fang, Qingguang Zhu\",\"doi\":\"10.2147/JPR.S505397\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic widespread pain (CWP) is a core symptom of fibromyalgia that is associated with significant morbidity and mortality. Despite the widespread recommendation for physical activity (PA) in management, the heterogeneity of PA prescriptions limits the in-depth evaluation of its efficacy. By triangulating clinical interventional evidence with human genetic evidence, the aim of this study was to investigate the role of influencing factors such as PA mode, course of treatment, and intensity on PA in the prevention and treatment of CWP.</p><p><strong>Methods: </strong>Ten international and regional databases were searched for articles published between January 2014 and July 2024. Randomized control trials with CWP or fibromyalgia as an entry criterion and PA as an intervention were included. Meta-analyses were performed using fixed- or random-effects models based on heterogeneity, and subgroup analyses were conducted. Mendelian randomization (MR) was used to estimate the effects of the genetic variants linked to PA intensity on CWP risk.</p><p><strong>Results: </strong>The analysis included 11 studies with 540 participants. PA effectively improved pain perception (MD: -1.47; 95% CI: -2.23, -0.72), depression (MD: -4.77; 95% CI: -7.40, -2.14), and overall quality of life (SMD: -1.43; 95% CI: -2.16, -0.69). MR analysis revealed that several PA intensities were associated with reduced susceptibility to CWP: walking for pleasure (OR: 0.950; 95% CI: 0.934-0.966), light do-it-yourself (DIY) (OR: 0.976; 95% CI: 0.961-0.992), strenuous sports (OR: 0.923; 95% CI: 0.880-0.967), and other exercises (OR: 0.957; 95% CI: 0.942-0.973).</p><p><strong>Conclusion: </strong>PA interventions are beneficial for reducing pain perception and mood disorders and enhancing the quality of life of patients with CWP. A treatment course of approximately three months is preferable, with Ba-Duan-Jin potentially more effective than other PAs, and high-intensity PA offers the most significant protective effect against CWP.</p>\",\"PeriodicalId\":16661,\"journal\":{\"name\":\"Journal of Pain Research\",\"volume\":\"18 \",\"pages\":\"1275-1289\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-03-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920634/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pain Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JPR.S505397\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pain Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JPR.S505397","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Effect of Physical Activity on Chronic Widespread Pain: Insights From Meta-Analysis and Two-Sample Mendelian Randomization.
Background: Chronic widespread pain (CWP) is a core symptom of fibromyalgia that is associated with significant morbidity and mortality. Despite the widespread recommendation for physical activity (PA) in management, the heterogeneity of PA prescriptions limits the in-depth evaluation of its efficacy. By triangulating clinical interventional evidence with human genetic evidence, the aim of this study was to investigate the role of influencing factors such as PA mode, course of treatment, and intensity on PA in the prevention and treatment of CWP.
Methods: Ten international and regional databases were searched for articles published between January 2014 and July 2024. Randomized control trials with CWP or fibromyalgia as an entry criterion and PA as an intervention were included. Meta-analyses were performed using fixed- or random-effects models based on heterogeneity, and subgroup analyses were conducted. Mendelian randomization (MR) was used to estimate the effects of the genetic variants linked to PA intensity on CWP risk.
Results: The analysis included 11 studies with 540 participants. PA effectively improved pain perception (MD: -1.47; 95% CI: -2.23, -0.72), depression (MD: -4.77; 95% CI: -7.40, -2.14), and overall quality of life (SMD: -1.43; 95% CI: -2.16, -0.69). MR analysis revealed that several PA intensities were associated with reduced susceptibility to CWP: walking for pleasure (OR: 0.950; 95% CI: 0.934-0.966), light do-it-yourself (DIY) (OR: 0.976; 95% CI: 0.961-0.992), strenuous sports (OR: 0.923; 95% CI: 0.880-0.967), and other exercises (OR: 0.957; 95% CI: 0.942-0.973).
Conclusion: PA interventions are beneficial for reducing pain perception and mood disorders and enhancing the quality of life of patients with CWP. A treatment course of approximately three months is preferable, with Ba-Duan-Jin potentially more effective than other PAs, and high-intensity PA offers the most significant protective effect against CWP.
期刊介绍：
Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
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