白血病的历史,重访。

IF 4.7 2区 医学 Q1 ONCOLOGY
Current Oncology Reports Pub Date : 2025-04-01 Epub Date: 2025-03-19 DOI:10.1007/s11912-025-01658-2
Carlos Ortiz-Hidalgo
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引用次数: 0

摘要

综述的目的:提供白血病的一般历史概述,强调导致其特征的早期发现。最近的发现:白血病的识别始于19世纪末显微镜的出现。列文虎克(Leeuwenhoek)和Swammerdam描述了红细胞,而Lieutaud首先观察到的是白球,后来被休森(Hewson)鉴定为淋巴细胞。Velpeau、donn、Bennett、Craigie、Virchow和Fuller的早期病例研究表明,白细胞增多症可以在没有感染的情况下发生。维尔肖创造了“白血病”一词,而贝内特则提出了“白血病”一词。诺伊曼认为骨髓是血细胞和白血病的来源,创造了“髓性白血病”一词,埃利希将白血病分为骨髓型和淋巴型。1914年,Boveri将染色体异常与癌症联系起来,1960年,Nowell和Hungerford发现了费城染色体。第一次世界大战中芥子气的使用导致了化疗药物的发展,如氯苯和丁硫凡。人类基因组计划进一步推进了白血病的诊断和治疗。白血病,像许多疾病一样,由于病毒、细菌和基因突变等致病因素的变化而进化,这些因素影响了其发病机制和治疗。毫无疑问,随着新的科学家致力于治愈这种毁灭性疾病,它将继续发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
History of Leukemia, Revisited.

Purpose of the review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization.

Recent findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term "leukemia," while Bennett proposed "leucocythemia." Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term "myelogenous leukemia," and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease.

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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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