粘蛋白5AC作为无梗锯齿状病变的生物标志物：来自系统回顾和荟萃分析的结果

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-05-01 DOI:10.14309/ctg.0000000000000831

Kevin Liu, Moniyka Sachar, Violeta Popov, Ziheng Pei, Giulio Quarta

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引用次数: 0

摘要

摘要：无梗锯齿状病变（sls）是一类难以通过现有筛查方法检测到的结肠息肉，但与结肠癌高度相关。为了提高检测效率，我们寻找了一种对ssl敏感的生物标志物。最近的内镜和组织病理学研究表明，SSLs与肠粘蛋白表达的改变有关，但这种情况发生的频率尚不清楚。我们对现有的病理研究进行了荟萃分析，将SSLs与正常结肠粘膜、管状腺瘤（TAs）、绒毛状腺瘤（VAs）、传统锯齿状腺瘤（TSAs）和增生性息肉（hp）的粘蛋白表达进行了比较。我们检索了Medline、Pubmed和Embase，发现440篇关于该主题的出版物，总共有18篇研究符合纳入标准。我们发现，与正常结肠粘膜相比，MUC5AC在SSLs中表达更为常见(OR=82.9, p

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Mucin 5AC as a Biomarker for Sessile Serrated Lesions: Results From a Systematic Review and Meta-Analysis.

Introduction: Sessile serrated lesions (SSLs) are a class of colon polyps challenging to detect through current screening methods but highly associated with colon cancer. To improve detection, we sought a biomarker sensitive for SSLs. Recent endoscopic and histopathologic studies suggest that SSLs are associated with alterations in intestinal mucin expression, but the frequency with which this occurs is not known.

Methods: We performed a meta-analysis of available pathologic studies comparing mucin expression on SSLs to normal colonic mucosa, tubular adenomas, villous adenomas, traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). We searched Medline, Pubmed, and Embase and found 440 publications in this topic, and 18 total studies met inclusion.

Results: We found that MUC5AC expression was more common in SSLs compared to normal colonic mucosa (OR = 82.9, P < 0.01), tubular adenoma (OR = 11, P < 0.01), and TSAs (OR = 3.6, P = 0.04). We found no difference in MUC5AC expression between SSLs versus HPs (OR = 2.1, P = 0.09) and no difference in MUC5AC expression between left colon and right colon HPs, with an OR = 1.8, P = 0.23.

Discussion: We found that MUC5AC expression was found commonly on villous adenoma, SSLs, and TSAs while the frequency on colon cancers declined. MUC5AC is also upregulated in inflammatory bowel disease and in response to intestinal infections. MUC5AC expression highlights the potential of mucins as useful biomarkers, though not specific to SSLs. Further research into the clinical utility of MUC5AC as a pathologic or fecal biomarker could enhance SSL detection.

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.