多功能Sr/ zn掺杂TiO2微孔/纳米孔涂层通过调节骨相关细胞的信号串扰促进骨整合

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2025-03-19 DOI:10.1016/j.cej.2025.161734

Tian-Xia Zheng, Nuo-Ya Yang, Jiu-Peng Deng, Wei Dong, Li-Fang Feng, , Jin-Ping Yang, Xin-Jia Cai, Yan Liu, Meng-Chun Qi

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引用次数: 0

摘要

增强骨整合对于钛（Ti）种植体在骨科和牙科应用中的长期成功至关重要。本研究开发了一种锶(Sr)/锌（Zn）掺杂的TiO2微孔/纳米孔涂层，该涂层在不改变其他主要物理化学性质的情况下增加了表面亲水性。该涂层具有优异的成骨、抗菌和血管生成特性，促进成骨前细胞分化、细菌抑制、微血管形成和血管生成基因表达。在间接共培养系统中，它通过调节骨相关细胞（尤其是RAW264.7巨噬细胞）之间的信号串扰，促进成骨细胞分化和血管生成。大鼠骨整合模型证实了细胞间信号串串通过成骨-血管紧密耦合和早期种植体周围成骨/血管生成基因的活跃表达，有助于最终增强血管化骨整合。这些发现突出了Sr/ zn掺杂TiO2涂层在提高种植体质量和耐久性方面的多功能和临床潜力。

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Multifunctional Sr/Zn-doped TiO2 micro/nanoporous coating enhances osseointegration by modulating signaling crosstalk of bone-related cells

Enhancing osseointegration is crucial for the long-term success of titanium (Ti) implants in orthopedic and dental applications. This study developed a strontium (Sr)/zinc (Zn)-doped TiO₂ micro/nanoporous coating, which increased surface hydrophilicity, without altering other main physicochemical properties. The coating exhibited excellent osteogenic, antibacterial, and angiogenic properties, promoting preosteoblast differentiation, bacterial inhibition, microvessel formation, and angiogenic gene expression. In an indirect co-culture system, it enhanced osteoblast differentiation and angiogenesis by modulating signaling crosstalk among bone-related cells, particularly RAW264.7 macrophages. A rat bone integration model confirmed the intercellular signaling crosstalk through tight osteoblast-vascular coupling and active osteogenic/angiogenic gene expression in the early peri-implant area, contributing to final enhanced vascularized osseointegration. These findings highlight the Sr/Zn-doped TiO₂ coating’s multifunctional capabilities and clinical potential for improved implant quality and durability.

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.