癌症研究需要神经科学和神经科学家

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-03-20 DOI:10.1038/s41593-025-01925-2

Michelle Monje, Frank Winkler

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引用次数: 0

摘要

神经系统可以驱动癌症的发生、生长、扩散和治疗抵抗，而癌症可以以进一步支持疾病进展的方式操纵神经系统。在大脑或身体其他部位生长的肿瘤通过神经元与癌细胞突触的相互作用和旁分泌串扰，以电路特定的方式与神经元网络连接。此外，神经因素控制着肿瘤环境的关键组成部分，如免疫系统，癌症可以以恶性细胞固有的方式利用神经机制。在这里，我们就癌症神经科学这一新兴领域提供个人观点，并强调从神经科学的角度与神经科学家一起进行癌症研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cancer research needs neuroscience and neuroscientists

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Cancer research needs neuroscience and neuroscientists

The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors growing within the brain or elsewhere in the body connect with neuronal networks in circuit-specific manners, via neuron-to-cancer synaptic interactions and paracrine crosstalk. Moreover, neural factors govern critical components of the tumor environment, such as the immune system, and cancer can use neural mechanisms in a malignant cell-intrinsic manner. Here we provide a personal view on the burgeoning field of cancer neuroscience and highlight the need to approach cancer research from a neuroscience perspective — together with neuroscientists.

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.