肠上皮细胞的表观遗传流动性符合表型可塑性

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-03-20 DOI:10.1016/j.chembiol.2025.02.007

Swarnabh Bhattacharya , Ramesh A. Shivdasani

引用次数: 0

摘要

肠隐窝内的分化祖细胞对干细胞的损耗作出反应，恢复到多能状态。在Nature Cell Biology 2月刊上，Pashos等人1揭示了H3K36甲基化在细胞类型限制性基因中帮助维持细胞分化状态，从而调节细胞可塑性和再生反应的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells

Differentiated progenitors in intestinal crypts react to stem cell attrition by reverting to the multipotent state. In the February issue of Nature Cell Biology, Pashos et al.¹ reveal a role for H3K36 methylation at cell-type-restricted genes in helping maintain differentiated cell states, hence regulating cell plasticity and regenerative responses.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.