性别对巴西肺结核患者吡嗪酰胺和尿酸血清水平的影响。

IF 1.7 4区 医学 Q4 INFECTIOUS DISEASES
Carlos Augusto Abreu Albério, Juan Gonzalo Bardalez Rivera, Alberto Camarão de Sousa, Luann Wendel Pereira de Sena, José Luiz Fernandes Vieira
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引用次数: 0

摘要

抗结核药物的不良反应可导致放弃治疗,延长疾病负担。性在吡嗪酰胺暴露和尿酸代谢中的作用提出了它对结核患者关节痛和高尿酸血症发生率的影响的问题。鉴于文献中关于不良反应率性别差异的证据有限,本研究比较了男女肺结核患者血清吡嗪酰胺和尿酸水平,以及高尿酸血症和关节痛的发生率。采用分光光度法测定尿酸水平,高效液相色谱法测定血清吡嗪酰胺水平。共有88名患者参加了这项研究。平均体重、吡嗪酰胺剂量和中位尿酸水平在两性之间相似。然而,男性高尿酸血症的比例高于女性。吡嗪酰胺最大浓度范围为10 ~ 98µg/mL,雌性高于雄性。关节痛的总发生率为25%,主要发生在高尿酸血症的男性患者中。关节痛患者血清吡嗪酰胺水平高于无关节痛患者。在两种性别中,没有发现药物水平和尿酸之间的显著相关性。总之,性别影响吡嗪酰胺暴露、关节痛和高尿酸血症发生率。密切监测尿酸水平可能有助于提高结核病治疗的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The influence of sex on pyrazinamide and uric acid serum levels in Brazilian patients treated for pulmonary tuberculosis.

Adverse reactions to antituberculosis drugs can lead to treatment abandonment, prolonging the burden of the disease. The role of sex in pyrazinamide exposure and uric acid metabolism raises questions about its influence on the rates of arthralgia and hyperuricemia in patients with tuberculosis. Given the limited evidence in the literature regarding sex-related differences in adverse reaction rates, this study compares serum levels of pyrazinamide and uric acid, as well as the rates of hyperuricemia and arthralgia, between male and female patients with pulmonary tuberculosis. Uric acid levels were measured using the spectrophotometric uricase method, and serum pyrazinamide levels were determined by high-performance liquid chromatography. A total of 88 patients were enrolled in the study. The mean weight, pyrazinamide dosage, and median uric acid levels were similar between sexes. However, the proportion of males with hyperuricemia was higher than that of females. Pyrazinamide maximum concentrations ranged from 10 to 98 µg/mL and were higher in females than in males. The overall rate of arthralgia was 25%, occurring primarily in male patients with hyperuricemia. Serum pyrazinamide levels were higher in patients with arthralgia compared to those without it. No significant correlations were found between drug levels and uric acid in either sex. In conclusion, sex influences pyrazinamide exposure and arthralgia and hyperuricemia rates. Close monitoring of uric acid levels may help improve adherence to tuberculosis therapy.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
100
审稿时长
6-12 weeks
期刊介绍: The Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is a journal devoted to research on different aspects of tropical infectious diseases. The journal welcomes original work on all infectious diseases, provided that data and results are directly linked to human health. The journal publishes, besides original articles, review articles, case reports, brief communications, and letters to the editor. The journal publishes manuscripts only in English. From 2016 on, the Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is published online only, maintaining the free access. For more information visit: - http://www.scielo.br/rimtsp - http://www.imt.usp.br/revista-imt/
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