Rongli An, Xianli Zhang, Xianglei Luo, Zhongxia Zhao, Xiaohong Zhen
{"title":"早发性精神分裂症患者认知功能障碍与氧化应激标志物的关系","authors":"Rongli An, Xianli Zhang, Xianglei Luo, Zhongxia Zhao, Xiaohong Zhen","doi":"10.12669/pjms.41.3.9999","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia(EOS).</p><p><strong>Methods: </strong>This was a retrospective study. A total of 42 patients with EOS admitted to The Eighth Hospital of Shijiazhuang from December 2021 to December 2023 and 42 healthy volunteers were included in this study and classified as the observation group and the control group. Cognitive impairment and oxidative stress markers were assessed in both groups. The Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB) was used to evaluate cognitive function, and the serum levels of superoxide dismutase(SOD), malondialdehyde, glutathione peroxidase(GSH-Px), catalase, homocysteine, and nitric oxide(NO) were measured. Pearson correlation analysis was conducted to clarity the relationship between cognitive function and oxidative stress markers.</p><p><strong>Results: </strong>The SOD and GSH-Px levels in the observation group were lower than in the control group, while homocysteine, catalase, malondialdehyde, and NO levels were higher in the observation group. Compared to the control group, patients in the observation group scored significantly lower for information processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition (<i>P</i>< 0.01, respectively). SOD and malondialdehyde levels were found to have a significant negative correlation with information processing speed, with r values of -0.342 and -0.350, respectively (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Cognitive impairment in patients with EOS appears to be associated with oxidative stress. There is a significant negative correlation between the levels of SOD and malondialdehyde and information processing speed.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 3","pages":"867-871"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911765/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia.\",\"authors\":\"Rongli An, Xianli Zhang, Xianglei Luo, Zhongxia Zhao, Xiaohong Zhen\",\"doi\":\"10.12669/pjms.41.3.9999\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia(EOS).</p><p><strong>Methods: </strong>This was a retrospective study. A total of 42 patients with EOS admitted to The Eighth Hospital of Shijiazhuang from December 2021 to December 2023 and 42 healthy volunteers were included in this study and classified as the observation group and the control group. Cognitive impairment and oxidative stress markers were assessed in both groups. The Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB) was used to evaluate cognitive function, and the serum levels of superoxide dismutase(SOD), malondialdehyde, glutathione peroxidase(GSH-Px), catalase, homocysteine, and nitric oxide(NO) were measured. Pearson correlation analysis was conducted to clarity the relationship between cognitive function and oxidative stress markers.</p><p><strong>Results: </strong>The SOD and GSH-Px levels in the observation group were lower than in the control group, while homocysteine, catalase, malondialdehyde, and NO levels were higher in the observation group. Compared to the control group, patients in the observation group scored significantly lower for information processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition (<i>P</i>< 0.01, respectively). SOD and malondialdehyde levels were found to have a significant negative correlation with information processing speed, with r values of -0.342 and -0.350, respectively (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Cognitive impairment in patients with EOS appears to be associated with oxidative stress. There is a significant negative correlation between the levels of SOD and malondialdehyde and information processing speed.</p>\",\"PeriodicalId\":19958,\"journal\":{\"name\":\"Pakistan Journal of Medical Sciences\",\"volume\":\"41 3\",\"pages\":\"867-871\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911765/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Medical Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12669/pjms.41.3.9999\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.41.3.9999","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia.
Objective: To investigate the relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia(EOS).
Methods: This was a retrospective study. A total of 42 patients with EOS admitted to The Eighth Hospital of Shijiazhuang from December 2021 to December 2023 and 42 healthy volunteers were included in this study and classified as the observation group and the control group. Cognitive impairment and oxidative stress markers were assessed in both groups. The Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB) was used to evaluate cognitive function, and the serum levels of superoxide dismutase(SOD), malondialdehyde, glutathione peroxidase(GSH-Px), catalase, homocysteine, and nitric oxide(NO) were measured. Pearson correlation analysis was conducted to clarity the relationship between cognitive function and oxidative stress markers.
Results: The SOD and GSH-Px levels in the observation group were lower than in the control group, while homocysteine, catalase, malondialdehyde, and NO levels were higher in the observation group. Compared to the control group, patients in the observation group scored significantly lower for information processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition (P< 0.01, respectively). SOD and malondialdehyde levels were found to have a significant negative correlation with information processing speed, with r values of -0.342 and -0.350, respectively (P < 0.05).
Conclusion: Cognitive impairment in patients with EOS appears to be associated with oxidative stress. There is a significant negative correlation between the levels of SOD and malondialdehyde and information processing speed.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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