利用中医药治疗癌症的力量:纳米载体的作用。

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S502104
Ziyu Fu, Shengmei Wang, Xin Zhou, Linqi Ouyang, Zhen Chen, Guiming Deng
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引用次数: 0

摘要

几个世纪以来,中医在治疗肿瘤方面具有一定的优势。然而,由于其水溶性差、生物利用度低和潜在毒性,将其有效递送到靶点可能是一个重大挑战。基于中药有效成分的纳米载体,如脂质体、聚合物纳米颗粒、无机纳米颗粒和有机/无机纳米混合物,是改善中药给药的一种有前景的策略,可以获得更高的治疗效果和更少的副作用。因此,本文拟对中药纳米制剂在肿瘤中的应用进行综述。首先介绍了中药纳米制剂的分类和合成方法。第二部分主要介绍中药纳米制剂在治疗过程中的不同反应,介绍中药纳米制剂如何在抗肿瘤治疗中发挥作用。第三部分重点研究中药纳米制剂在肿瘤治疗中的不同反应模式。第四部分阐述了中药纳米制剂在癌症治疗中的应用。最后,提出了相关领域有待探索的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing the Power of Traditional Chinese Medicine in Cancer Treatment: The Role of Nanocarriers.

For centuries, traditional Chinese medicine (TCM) has had certain advantages in the treatment of tumors. However, due to their poor water solubility, low bioavailability and potential toxicity, their effective delivery to target sites can be a major challenge. Nanocarriers based on the active ingredients of TCM, such as liposomes, polymer nanoparticles, inorganic nanoparticles, and organic/inorganic nanohybrids, are a promising strategy to improve the delivery of TCM, resulting in higher therapeutic outcomes and fewer side effects. Therefore, this article intends to review the application of Chinese medicine nano preparation in tumor. Firstly, we introduce the classification and synthesis of nanometer preparations of Chinese medicine. The second part mainly introduces the different responses of TCM nano-preparations in the course of treatment to introduce how TCM nano-preparations play a role in anti-tumor therapy. The third part focuses on Different response modes of Chinese medicine nano preparations in tumor therapy. The fourth part elucidates the application of Chinese medicine nano preparations in the treatment of cancer. Finally, the research direction to be explored in related fields is put forward.

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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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