stat1驱动的干扰素特征与T-ALL中JAK抑制剂的敏感性相关。

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2025-06-05 DOI:10.1182/blood.2025028566

Jason Xu, Jonathan H Sussman, Austin Yang, Satoshi Yoshimura, Jianzhong Hu, Changya Chen, Tiffaney Vincent, Shovik Bandyopadhyay, Elizabeth Y Li, Tristan Lim, Omar Elghawy, Adam Barsouk, Damjan Karanfilovski, Shira L Wald, Gregory M Chen, David Wu, Haley Newman, Alexander Li, Yusha Sun, Chia-Hui Chen, Kathrin Bernt, Brent L Wood, Stuart S Winter, Kimberly P Dunsmore, Elizabeth Raetz, Meenakshi Devidas, Stanley Pounds, Mignon Loh, Stephen P Hunger, Mark Y Chiang, Caroline Diorio, Danika Di Giacomo, Petri Pölönen, Charles G Mullighan, Jun J Yang, Kai Tan, David T Teachey

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引用次数: 0

摘要

我们利用单细胞基因组学来表征一名接受COG AALL0434治疗的T-ALL患者，该患者的临床结果不佳，尽管基因组特征有利，鉴定了stat1介导的干扰素相关转录特征和炎症微环境，该微环境与对小分子jak抑制的敏感性相关。

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STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL.

Abstract: We used single-cell genomics to characterize a patient with T-cell acute lymphoblastic leukemia treated in the Children's Oncology Group AALL0434 trial with poor clinical outcome despite favorable genomic features, identifying a STAT1-mediated interferon-related transcriptional signature and inflammatory microenvironment associated with sensitivity to small-molecule JAK inhibition.

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.