Aida Mehdipour, Maryam Masoumi, Roohollah Fateh, Mohammad Aghaali, Faezeh Mohammadidana, Ali Saleh, Alireza Rasouli, Faezeh Kabiri
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引用次数: 0
摘要
背景和目的：系统性红斑狼疮（SLE）和类风湿性关节炎（RA）是一种复杂的自身免疫性疾病，会出现一系列全身和口腔表现，包括龋齿和口腔微生物组特征的改变。本研究的目的是比较系统性红斑狼疮和类风湿性关节炎患者龈上牙菌斑和龋齿的真菌和细菌特征：本研究对 91 名参与者（31 名 RA 患者、30 名狼疮患者和 30 名对照组患者）进行了描述性横断面分析。蛀牙、缺失牙和填充牙（DMFT）和国际龋齿检测评估系统（ICDAS）指数用于调查蛀牙情况。DAS-28 指数用于评估 RA 的严重程度，SLEDAI-2 K 指数用于评估狼疮的严重程度。龈上牙菌斑变异链球菌、乳酸杆菌和白色念珠菌的菌落数分别用唾液酸琼脂（MSA）、德曼-罗戈萨-沙佩琼脂（MRS）和含氯霉素的沙保露葡萄糖琼脂（SC）培养基进行评估。数据采用单因素方差分析、Kruskal -Wallis、k2、费雪检验和斯皮尔曼相关系数进行分析：结果：教育水平（P = 0.030）、DMFT、ICDAS、MSA 和 SC 指数的平均值（P 结论：蛀牙与真菌和细菌之间存在统计学意义上的显著关系：龈上牙菌斑患者的蛀牙、真菌和细菌菌群高于健康组。建议这些患者更加注意口腔卫生，定期进行口腔检查。
Comparative study of the profile of supragingival dental plaque and tooth decay in patients with lupus erythematosus and rheumatoid arthritis.
Background and objectives: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases that present with a range of systemic and oral manifestations including dental decay and alterations in the oral microbiome profile. The purpose of this study was to compare the fungal and bacterial profile of supragingival dental plaque and dental caries in patients with SLE and RA.
Methods: The present descriptive-cross-sectional-analytical study was conducted on 91 participants (31 RA, 30 lupus, and 30 control groups). Decayed, Missing, and Filled teeth (DMFT) and The International Caries Detection Assessment System (ICDAS) indices were used to investigate tooth decay. The DAS-28 index was used to assess the severity of RA, and the SLEDAI-2 K index was used to evaluate the severity of lupus. The number of supragingival dental plaque Streptococcus mutans, Lactobacillus spp. and Candida albicans colonies were evaluated using Mitis Salivarius Agar (MSA), deMan-Rogosa-Sharpe agar (MRS) and Sabouraud Dextrose Agar with Chloramphenicol (SC) culture medium, respectively. Data were analyzed using one-way ANOVA, Kruskal -Wallis, k2, Fisher's tests, and Spearman's correlation coefficient.
Results: A statistically significant relationship was observed between the education level (P = 0.030), mean of DMFT, ICDAS, MSA and SC indices (P < 0.001) with the type of disease. The control and RA group showed significantly higher MRS index than the lupus group (P < 0.001). There was significant and positive correlation between the severity of the disease in lupus patients and SC (Candida albicans) (P < 0.001, R = 0.698) and MRS (P = 0/020, R = 0.408) indices.
Conclusion: Dental decay and the fungal and bacterial flora of supragingival dental plaque patients are higher than in the healthy group. It is recommended that these patients pay more attention to their oral hygiene and undergo periodic oral examinations.
期刊介绍：
BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.
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