铜离子对催化双相体系中乙烯基砜的共轭硼化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-02-25 DOI:10.1039/d5ob00242g

Siyu Jiang , Yicen Ge , Ai Zhang , Silong Hu , Tao Jin , Jian Chen , Huangfeng Zhang , Yao Qin , Xiaoyan Ma , Jinghua Tang , Jinyu Liu

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引用次数: 0

摘要

本文报道了通过离子对介导的乙烯基砜的共轭硼化反应，该反应可以在13-98%的收率下高效合成具有多种功能的β-磺酰基醇。进一步的机理研究表明，阴离子硼铜中间体的形成在动力学上加速了反应物的跨相转移，并增强了硼基的亲核性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system†

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Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system†

Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13–98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.