新型嘧啶基磺酰胺衍生物作为GPR17调节剂。

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-01-27 eCollection Date: 2025-03-13 DOI:10.1021/acsmedchemlett.5c00012

Taoqian Zhao, Steven H Liang

引用次数: 0

摘要

本发明涉及式1所示的新型嘧啶基磺酰胺衍生物。这些化合物被专门设计用于结合和调节GPR17的活性，使其特别有希望用于治疗与GPR17拮抗相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators.

The present invention relates to novel pyrimidinyl sulfonamide derivatives represented by formula I. These compounds are specifically designed to bind to and modulate GPR17 activities, making them particularly promising for treating diseases associated with GPR17 antagonism.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.