用于σ键插入反应的张力双根碱：药物发现的一个突破

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2025-04-10 DOI:10.1016/j.chempr.2025.102524

Yoshio Barrera , Florian F. Mulks

引用次数: 0

摘要

Houk、Garg和同事在《自然》杂志上报道了一种新的、有趣的合成方法，在温和的条件和环境温度下，通过σ-键插入，沿着双自由基途径将张力环烯和双环[1.1.0]丁烷偶联。几何畸变诱导双自由基行为，驱动反应。本研究实现了功能化双环[2.1.1]己烷的直接合成，为药物发现开辟了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strained diradicaloids for σ-bond-insertion reactions: A breakthrough in drug discovery

Houk, Garg, and colleagues report in Nature a new and intriguing synthetic method for coupling strained cyclic allenes and bicyclo[1.1.0]butanes through σ-bond insertion along a diradical pathway under mild conditions and ambient temperature. Geometric distortion induces diradical behavior, driving the reaction. This study enables the direct synthesis of functionalized bicyclo[2.1.1]hexanes, opening new avenues in drug discovery.

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.