用光触发质子泵控制凝胶形成的化学反应网络

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-03-19 DOI:10.1021/acs.langmuir.4c04581

Jacqueline Figueiredo da Silva, Ardeshir Roshanasan, Marcel Bus, Dimitrios Fotiadis, Armin W. Knoll, Jan H. van Esch, Heiko Wolf

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引用次数: 0

摘要

自然界中许多代谢过程是由外部刺激如光和pH值变化控制的，这为合成和生物应用提供了机会。在开发多传感器设备时，我们将亚微米紫色膜片集成到表面上，每个膜片都含有细菌视紫红质。细菌视紫红质是一种光驱动质子泵。我们监测了该系统与ph响应超分子水凝胶之间的相互作用，以评估纤维基质的生长。最初的光刺激诱导膜表面的局部pH值降低，从而催化水凝胶内的纤维生成。利用液体原子力显微镜和共聚焦激光扫描显微镜，我们实时观察了水凝胶的形态发生和结构适应。该系统巧妙地调节了微尺度的pH环境，在水凝胶基质中促进了目标纤维的发育。这阐明了模拟自然生物过程的工程响应材料的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Control of a Gel-Forming Chemical Reaction Network Using Light-Triggered Proton Pumps

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Control of a Gel-Forming Chemical Reaction Network Using Light-Triggered Proton Pumps

Numerous metabolic processes in nature are governed by extrinsic stimuli such as light and pH variations, which afford opportunities for synthetic and biological applications. In developing a multisensor apparatus, we have integrated submicrometer purple membrane patches, each harboring bacteriorhodopsin, onto a surface. Bacteriorhodopsin is a light-driven proton pump. We conducted monitoring of the interactions between this system and a pH-responsive supramolecular hydrogel to evaluate fibrous matrix growth. Initial photostimulation induced localized reductions in pH at the membrane surface, thereby catalyzing fibrogenesis within the hydrogel. Utilizing liquid atomic force microscopy alongside confocal laser scanning microscopy, we observed the hydrogel’s morphogenesis and structural adaptations in real time. The system adeptly modulated microscale pH environments, fostering targeted fibrous development within the hydrogel matrix. This elucidates the potential for engineering responsive materials that emulate natural bioprocesses.

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).