T细胞命运决定的表观遗传景观

IF 27.7 1区 医学 Q1 IMMUNOLOGY
Atishay Jay, Carlos M. Pondevida, Golnaz Vahedi
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引用次数: 0

摘要

特异性T细胞亚群介导适应性免疫,响应细胞因子信号和特异性转录因子活性。T细胞的表观遗传景观在促进和建立T细胞命运决定中起着重要作用。在这里,我们回顾了转录因子、组蛋白修饰、DNA甲基化和三维染色质组织之间的相互作用,以定义T细胞表观遗传景观的关键要素。我们介绍了测序,显微镜和蛋白质组学领域的关键技术,这些技术使表观遗传景观的多尺度分析成为可能。我们强调了多能祖细胞在发育过程中向T细胞谱系转移时表观遗传景观的巨大变化,并讨论了有利于CD4+和CD8+ T细胞出现的表观遗传变化。最后,我们讨论了表观遗传标记的遗传及其对免疫反应的潜在影响,以及具有潜在表观遗传调控的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The epigenetic landscape of fate decisions in T cells

The epigenetic landscape of fate decisions in T cells

The epigenetic landscape of fate decisions in T cells
Specialized T cell subsets mediate adaptive immunity in response to cytokine signaling and specific transcription factor activity. The epigenetic landscape of T cells has an important role in facilitating and establishing T cell fate decisions. Here, we review the interplay between transcription factors, histone modifications, DNA methylation and three-dimensional chromatin organization to define key elements of the epigenetic landscape in T cells. We introduce key technologies in the areas of sequencing, microscopy and proteomics that have enabled the multi-scale profiling of the epigenetic landscape. We highlight the dramatic changes of the epigenetic landscape as multipotent progenitor cells commit to the T cell lineage during development and discuss the epigenetic changes that favor the emergence of CD4+ and CD8+ T cells. Finally, we discuss the inheritance of epigenetic marks and its potential effects on immune responses as well as therapeutic strategies with potential for epigenetic regulation. Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4+ and CD8+ T cells during development and differentiation.
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来源期刊
Nature Immunology
Nature Immunology 医学-免疫学
CiteScore
40.00
自引率
2.30%
发文量
248
审稿时长
4-8 weeks
期刊介绍: Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
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