Aleksi Tarkkonen, Iiris Kyläheiko, Jussi Inkeri, Marika I Eriksson, Lena M Thorn, Paula A Summanen, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola
{"title":"无神经症状的中年1型糖尿病患者脑血管疾病的进展","authors":"Aleksi Tarkkonen, Iiris Kyläheiko, Jussi Inkeri, Marika I Eriksson, Lena M Thorn, Paula A Summanen, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola","doi":"10.2337/dc24-1825","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes.</p><p><strong>Research design and methods: </strong>A total of 172 individuals with type 1 diabetes were re-examined with brain MRI 7.5 years after their initial visit. Baseline predictors of changes in CSVD, particularly cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) were analyzed.</p><p><strong>Results: </strong>The proportion of individuals with type 1 diabetes with CSVD increased from 36% to 70% (P < 0.001), CMBs increased from 17% to 33% (P < 0.001), and WMHs from 23% to 63% (P < 0.001) at follow-up. The increase in CMBs was associated with baseline systolic blood pressure, HbA1c, and preexisting CMBs. The increases in CSVD and WMHs were associated only with age.</p><p><strong>Conclusions: </strong>The prevalence of CSVD doubled over a 7.5-year period in middle-aged individuals with type 1 diabetes.</p>","PeriodicalId":93979,"journal":{"name":"Diabetes care","volume":" ","pages":"776-780"},"PeriodicalIF":16.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes.\",\"authors\":\"Aleksi Tarkkonen, Iiris Kyläheiko, Jussi Inkeri, Marika I Eriksson, Lena M Thorn, Paula A Summanen, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola\",\"doi\":\"10.2337/dc24-1825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes.</p><p><strong>Research design and methods: </strong>A total of 172 individuals with type 1 diabetes were re-examined with brain MRI 7.5 years after their initial visit. Baseline predictors of changes in CSVD, particularly cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) were analyzed.</p><p><strong>Results: </strong>The proportion of individuals with type 1 diabetes with CSVD increased from 36% to 70% (P < 0.001), CMBs increased from 17% to 33% (P < 0.001), and WMHs from 23% to 63% (P < 0.001) at follow-up. The increase in CMBs was associated with baseline systolic blood pressure, HbA1c, and preexisting CMBs. The increases in CSVD and WMHs were associated only with age.</p><p><strong>Conclusions: </strong>The prevalence of CSVD doubled over a 7.5-year period in middle-aged individuals with type 1 diabetes.</p>\",\"PeriodicalId\":93979,\"journal\":{\"name\":\"Diabetes care\",\"volume\":\" \",\"pages\":\"776-780\"},\"PeriodicalIF\":16.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2337/dc24-1825\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2337/dc24-1825","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes.
Objective: To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes.
Research design and methods: A total of 172 individuals with type 1 diabetes were re-examined with brain MRI 7.5 years after their initial visit. Baseline predictors of changes in CSVD, particularly cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) were analyzed.
Results: The proportion of individuals with type 1 diabetes with CSVD increased from 36% to 70% (P < 0.001), CMBs increased from 17% to 33% (P < 0.001), and WMHs from 23% to 63% (P < 0.001) at follow-up. The increase in CMBs was associated with baseline systolic blood pressure, HbA1c, and preexisting CMBs. The increases in CSVD and WMHs were associated only with age.
Conclusions: The prevalence of CSVD doubled over a 7.5-year period in middle-aged individuals with type 1 diabetes.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
