边缘型人格障碍和精神分裂症的神经软症状。

IF 4 2区 医学 Q1 PSYCHIATRY
Marie-Luise Otte, Mike M Schmitgen, Nadine D Wolf, Katharina M Kubera, Yunus Balcik, Chantal Tech, Mert Koc, Yéléna Le Prieult, Fabio Sambataro, Geva A Brandt, Stefan Fritze, Dusan Hirjak, Robert Christian Wolf
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引用次数: 0

摘要

背景:神经软征(NSS)是在各种神经发育起源的精神障碍中观察到的细微感觉运动异常。虽然NSS在精神分裂症(SZ)患者中得到了广泛的研究,但初步证据也表明,NSS也存在于边缘型人格障碍(BPD)患者中。然而,与SZ相比,BPD中NSS严重程度的诊断检查仍然缺乏。方法:采用海德堡NSS量表(Heidelberg NSS scale, HNSS)对BPD (n = 45)、SZ (n = 30)和健康对照组(HC) (n = 32)三组女性进行NSS检测。对BPD、SZ、HC和HNSS评分联合进行多变量方差分析(MANOVA)。采用线性判别分析(LDA)进行事后检验。在BPD组,NSS评分与抑郁症状(HAMD-21)、冲动性(BIS-11)、分离症状(DTS)、童年创伤(CTQ)和边缘性症状(BSL-23)之间存在部分Spearman相关性(以年龄和药物作为协变量)。结果:BPD组NSS水平明显高于hcc组。对于BPD, NSS与童年创伤和抑郁症状之间存在显著关联。方差分析显示组间差异显著,LDA在HC、SZ和BPD患者之间存在差异,但在患者组间无差异。结论:BPD患者的NSS水平明显高于HC。BPD患者的NSS与童年创伤有显著关联,支持“两次打击”模型。重要的是,BPD和SZ患者可能表现出相似的NSS模式,这表明感觉运动功能障碍是一种跨诊断现象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurological soft signs in borderline personality disorder and schizophrenia.

Background: Neurological soft signs (NSS) are subtle sensorimotor abnormalities that have been observed in various mental disorders with neurodevelopmental origin. While NSS have been extensively examined in patients with schizophrenia (SZ), preliminary evidence also suggests that NSS are also present in patients with borderline personality disorder (BPD). However, a transdiagnostic examination of the severity of NSS in BPD compared to SZ is still lacking.

Methods: Here, NSS were examined with the Heidelberg NSS scale (HNSS) in three groups of female subjects: BPD (n = 45), SZ (n = 30) and healthy controls (HC) (n = 32). Multivariate analysis of variance (MANOVA) was conducted jointly for BPD, SZ, and HC and HNSS subscores. Post hoc tests were performed using linear discriminant analysis (LDA). In the BPD group, partial Spearman correlations (with age and medication as covariates) were performed between NSS scores and depressive symptoms (HAMD-21), impulsivity (BIS-11), dissociative symptoms (DTS), childhood trauma (CTQ), and borderline symptoms (BSL-23).

Results: BPD showed significantly higher NSS levels compared to HCs. For the BPD, significant associations between NSS and childhood trauma and depressive symptoms were found. MANOVA showed a significant group difference, LDA differentiated between HC, and patients with SZ and BPD, but not between the patient groups.

Conclusions: Patients with BPD have significantly higher NSS levels than HC. NSS in BPD showed significant associations with childhood trauma, supporting a "two-hit" model. Importantly, patients with BPD and SZ may show similar NSS patterns, suggesting that sensorimotor dysfunction is a transdiagnostic phenomenon.

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来源期刊
CiteScore
6.00
自引率
9.80%
发文量
30
审稿时长
28 weeks
期刊介绍: Borderline Personality Disorder and Emotion Dysregulation provides a platform for researchers and clinicians interested in borderline personality disorder (BPD) as a currently highly challenging psychiatric disorder. Emotion dysregulation is at the core of BPD but also stands on its own as a major pathological component of the underlying neurobiology of various other psychiatric disorders. The journal focuses on the psychological, social and neurobiological aspects of emotion dysregulation as well as epidemiology, phenomenology, pathophysiology, treatment, neurobiology, genetics, and animal models of BPD.
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