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IF 1.8 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Medicine and Science Pub Date : 2025-03-01 DOI:10.1002/vms3.70280

Luo Xinyi, Liu Jinlong, Zhou Bin

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引用次数: 0

摘要

犬乳腺肿瘤 (CMT) 是老年母犬最常见的肿瘤类型。由于有些 CMT 是恶性的，预后较差，因此必须进行早期、精确和低侵入性诊断。细针穿刺细胞学（FNAC）和血液化验都是兽医学中常用的低创诊断方法。然而，应该找到完美的生物标志物来诊断和评估CMT的预后。本综述根据现有文献，重点介绍可通过 FNA 或血液样本检测的生物标志物。迄今为止，研究最多的 FNAC 生物标志物包括 Ki-67、人表皮生长因子受体 2 (HER-2)、雌激素受体 (ER)、孕酮受体 (PR)、P53、E-cadherin 和环氧化酶 2 (COX-2)。一些已被广泛研究的常见血液生物标记物包括乳酸脱氢酶（LDH）、C反应蛋白（CRP）、碳水化合物抗原15-3（CA15-3）和癌胚抗原（CEA）。还将提及新型生物标记物：癌症干细胞（CSCs）、循环肿瘤细胞（CTCs）、miRNAs 和循环无细胞 DNA（cfDNA）；它们都是有用的标记物。铜离子和血清铁蛋白（SF）是人类乳腺癌的良好标记物，它们也可能是候选的 CMTs 生物标记物。总之，许多生物标志物都适用于诊断和/或预后 CMTs；将其中几种结合起来可提高特异性；应进行更详细的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Low-Invasive Biomarkers of Canine Mammary Tumours.

Canine mammary tumours (CMTs) are the most common type of tumours in older bitches. An early, precise and low-invasive diagnosis is essential, due to some CMTs being malignant and having a poor prognosis. Fine needle aspiration cytology (FNAC) and blood tests are both low-invasive diagnostic methods that have been used in veterinary medicine. However, the perfect biomarkers should be identified to diagnose and evaluate the prognosis of CMTs. This review focuses on biomarkers that can be tested by FNA or blood samples based on current literature. Until now, the most studied biomarkers of FNAC, such as Ki-67, human epidermal growth factor receptor 2 (HER-2), oestrogen receptor (ER), progesterone receptor (PR), P53, E-cadherin and cyclooxygenase-2 (COX-2). Some common blood biomarkers that have been widely studied include lactate dehydrogenase (LDH), C-reactive protein (CRP), carbohydrate antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA). The novel biomarkers will also be mentioned: cancer stem cells (CSCs), circulating tumour cells (CTCs), miRNAs and circulating cell-free DNA (cfDNA); they are all useful markers. Copper ion and serum ferritin (SF) are good markers of human breast cancer; they may be candidates of CMTs biomarkers, too. In conclusion, many biomarkers are suitable for diagnosing and/or prognosing CMTs; combining a couple of them can increase the specificity; more detailed research should be done.

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来源期刊

Veterinary Medicine and Science Veterinary-General Veterinary

CiteScore

3.00

自引率

0.00%

发文量

296

期刊介绍： Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.