{"title":"血清铁参数是否与阻塞性睡眠呼吸暂停综合征的严重程度有关？","authors":"Merve Yumrukuz Şenel, Rabia Şahin, Mustafa Çolak, Hikmet Çoban, Fuat Erel, Nurhan Sarıoğlu","doi":"10.1007/s11325-025-03301-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the correlation and relationship between iron parameters including serum iron level, iron-binding capacity, ferritin, transferrin saturation, and the severity of OSAS in the patients who underwent polysomnography.</p><p><strong>Methods: </strong>We retrospectively reviewed 209 patients and divided the patients into two groups; AHI ≥ 30 and AHI < 30. The groups were compared using the Mann-Whitney U and the chi-square test. In addition, Spearman's correlation analysis was performed to analyze the correlation between AHI and iron parameters.</p><p><strong>Results: </strong>The mean age of the patients was 47.9 ± 13.7 (19-89) years. Of the 209 patients, 40.7% (n = 85) were female and 59.3% (n = 124) were male. Iron and transferrin saturation was significantly lower in the patients with AHI ≥ 30 compared to the patients with AHI < 30. In female patients, there wasn't any correlation between AHI and iron, ferritin, transferrin saturation, and iron-binding capacity. But, there was a significant negative correlation between the AHI and iron (r = -0.292, p = 0.001) and transferrin saturation (r = -0.349, p < 0.001) in male patients. Also, the AHI was significantly positively correlated with iron binding capacity (r = 0.307, p = 0.001) in male patients.</p><p><strong>Conclusion: </strong>Our results showed that iron levels were lower in severe OSAS. Suggesting that iron levels decrease as a result of oxidative stress and inflammation seen in OSAS, iron parameters may be a good biomarker in OSAS patients.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 2","pages":"132"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Are the serum iron parameters related to the severity of obstructive sleep apnea syndrome?\",\"authors\":\"Merve Yumrukuz Şenel, Rabia Şahin, Mustafa Çolak, Hikmet Çoban, Fuat Erel, Nurhan Sarıoğlu\",\"doi\":\"10.1007/s11325-025-03301-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the correlation and relationship between iron parameters including serum iron level, iron-binding capacity, ferritin, transferrin saturation, and the severity of OSAS in the patients who underwent polysomnography.</p><p><strong>Methods: </strong>We retrospectively reviewed 209 patients and divided the patients into two groups; AHI ≥ 30 and AHI < 30. The groups were compared using the Mann-Whitney U and the chi-square test. In addition, Spearman's correlation analysis was performed to analyze the correlation between AHI and iron parameters.</p><p><strong>Results: </strong>The mean age of the patients was 47.9 ± 13.7 (19-89) years. Of the 209 patients, 40.7% (n = 85) were female and 59.3% (n = 124) were male. Iron and transferrin saturation was significantly lower in the patients with AHI ≥ 30 compared to the patients with AHI < 30. In female patients, there wasn't any correlation between AHI and iron, ferritin, transferrin saturation, and iron-binding capacity. But, there was a significant negative correlation between the AHI and iron (r = -0.292, p = 0.001) and transferrin saturation (r = -0.349, p < 0.001) in male patients. Also, the AHI was significantly positively correlated with iron binding capacity (r = 0.307, p = 0.001) in male patients.</p><p><strong>Conclusion: </strong>Our results showed that iron levels were lower in severe OSAS. Suggesting that iron levels decrease as a result of oxidative stress and inflammation seen in OSAS, iron parameters may be a good biomarker in OSAS patients.</p>\",\"PeriodicalId\":21862,\"journal\":{\"name\":\"Sleep and Breathing\",\"volume\":\"29 2\",\"pages\":\"132\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep and Breathing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11325-025-03301-7\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep and Breathing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11325-025-03301-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Are the serum iron parameters related to the severity of obstructive sleep apnea syndrome?
Purpose: To evaluate the correlation and relationship between iron parameters including serum iron level, iron-binding capacity, ferritin, transferrin saturation, and the severity of OSAS in the patients who underwent polysomnography.
Methods: We retrospectively reviewed 209 patients and divided the patients into two groups; AHI ≥ 30 and AHI < 30. The groups were compared using the Mann-Whitney U and the chi-square test. In addition, Spearman's correlation analysis was performed to analyze the correlation between AHI and iron parameters.
Results: The mean age of the patients was 47.9 ± 13.7 (19-89) years. Of the 209 patients, 40.7% (n = 85) were female and 59.3% (n = 124) were male. Iron and transferrin saturation was significantly lower in the patients with AHI ≥ 30 compared to the patients with AHI < 30. In female patients, there wasn't any correlation between AHI and iron, ferritin, transferrin saturation, and iron-binding capacity. But, there was a significant negative correlation between the AHI and iron (r = -0.292, p = 0.001) and transferrin saturation (r = -0.349, p < 0.001) in male patients. Also, the AHI was significantly positively correlated with iron binding capacity (r = 0.307, p = 0.001) in male patients.
Conclusion: Our results showed that iron levels were lower in severe OSAS. Suggesting that iron levels decrease as a result of oxidative stress and inflammation seen in OSAS, iron parameters may be a good biomarker in OSAS patients.
期刊介绍：
The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep.
Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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