Alisha Vabba, Keisuke Suzuki, Milica Doric, Tim J Möller, Sarah Garfinkel, Hugo Critchley
{"title":"The Vagus Nerve as a Gateway to Body Ownership: taVNS Reduces Susceptibility to a Virtual Version of the Cardiac and Tactile Rubber Hand Illusion.","authors":"Alisha Vabba, Keisuke Suzuki, Milica Doric, Tim J Möller, Sarah Garfinkel, Hugo Critchley","doi":"10.1111/psyp.70040","DOIUrl":null,"url":null,"abstract":"<p><p>Transcutaneous auricular vagus nerve stimulation (taVNS) has been shown to influence cognitive and emotional function and enhance interoceptive awareness. This study investigates if taVNS effects extend to the experience of body ownership, as measured via susceptibility to the rubber hand illusion (RHI) in a virtual reality setting. The experiment involved 27 participants who underwent real and sham stimulation in two separate sessions while experiencing synchronous or asynchronous visuo-cardiac and visuo-tactile feedback on a virtual arm in place of their own. Results indicated that active compared to sham taVNS decreased sensitivity to the illusion in both cardiac and tactile trials. Specifically, a greater proprioceptive drift difference (PDD) toward the rubber hand was observed for synchronous compared to asynchronous trials only during sham (t(26) = -4.58, p<sub>bonf</sub> < 0.001) but not during active (p<sub>bonf</sub> = 1.00) stimulation. A similar pattern was also observed for subjective ownership, where synchronous trials led to greater subjective ownership than asynchronous trials only during sham (t(26) = -3.52, p<sub>bonf</sub> = 0.010) but not during active (p<sub>bonf</sub> = 1.00) stimulation. These findings suggest that stimulation might enhance body ownership, making individuals more attuned to their real bodily signals and less susceptible to bodily illusions. Additionally, physiological measures such as heart rate (HR), heart rate variability (HRV), and skin sympathetic nervous activity (SKNA) were assessed to explore the autonomic effects of taVNS. We observed a decrease in HR during active stimulation (t(26) = 4.30, p<sub>bonf</sub> < 0.001), and an increase in SKNA during both sham (t(26) = -4.40, p<sub>bonf</sub> < 0.001) and active stimulation (t(26) = -4.85, p<sub>bonf</sub> < 0.002). These findings contribute to the understanding of the vagus nerve's role in integrating visceral and somatosensory signals, with implications for clinical applications in conditions characterized by altered interoception and body ownership.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70040"},"PeriodicalIF":2.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913772/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychophysiology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1111/psyp.70040","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The Vagus Nerve as a Gateway to Body Ownership: taVNS Reduces Susceptibility to a Virtual Version of the Cardiac and Tactile Rubber Hand Illusion.
Transcutaneous auricular vagus nerve stimulation (taVNS) has been shown to influence cognitive and emotional function and enhance interoceptive awareness. This study investigates if taVNS effects extend to the experience of body ownership, as measured via susceptibility to the rubber hand illusion (RHI) in a virtual reality setting. The experiment involved 27 participants who underwent real and sham stimulation in two separate sessions while experiencing synchronous or asynchronous visuo-cardiac and visuo-tactile feedback on a virtual arm in place of their own. Results indicated that active compared to sham taVNS decreased sensitivity to the illusion in both cardiac and tactile trials. Specifically, a greater proprioceptive drift difference (PDD) toward the rubber hand was observed for synchronous compared to asynchronous trials only during sham (t(26) = -4.58, pbonf < 0.001) but not during active (pbonf = 1.00) stimulation. A similar pattern was also observed for subjective ownership, where synchronous trials led to greater subjective ownership than asynchronous trials only during sham (t(26) = -3.52, pbonf = 0.010) but not during active (pbonf = 1.00) stimulation. These findings suggest that stimulation might enhance body ownership, making individuals more attuned to their real bodily signals and less susceptible to bodily illusions. Additionally, physiological measures such as heart rate (HR), heart rate variability (HRV), and skin sympathetic nervous activity (SKNA) were assessed to explore the autonomic effects of taVNS. We observed a decrease in HR during active stimulation (t(26) = 4.30, pbonf < 0.001), and an increase in SKNA during both sham (t(26) = -4.40, pbonf < 0.001) and active stimulation (t(26) = -4.85, pbonf < 0.002). These findings contribute to the understanding of the vagus nerve's role in integrating visceral and somatosensory signals, with implications for clinical applications in conditions characterized by altered interoception and body ownership.
期刊介绍：
Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.
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