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IF 2.1 4区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

PROTEOMICS – Clinical Applications Pub Date : 2025-03-17 DOI:10.1002/prca.70003

Van Duc Pham, Jung-Hyung Lee, Doyun Shin, Hung M Vu, Junyang Jung, Manoj K Kashyap, Seung Hyeun Lee, Min-Sik Kim

引用次数: 0

摘要

长期以来，支气管肺泡灌洗液（BALF）一直被用于通过其细胞成分诊断各种肺部疾病。然而，支气管肺泡灌洗液中的生物大分子的临床用途在很大程度上仍未得到探索。最近，基于质谱的蛋白质组学被应用于分析 BALF 蛋白质组，以确定肺部疾病的新型生物标记物。本综述讨论了 BALF 蛋白质组学领域的最新进展，并强调了其作为不同肺部疾病生物标志物的宝贵来源的潜力。此外，我们还探讨了 BALF 研究的最新进展和发现。最后，我们探讨了目前的局限性，并提出了未来的方向和研究机会，以推进 BALF 的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases.

Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry-based proteomics has been applied to profile the BALF proteomes to identify novel biomarkers for lung diseases. This review discusses the current progress in the field of BALF proteomics and highlights its potential as a valuable source of biomarkers for different lung diseases. Additionally, we explored the latest advancements and findings from BALF studies. Finally, we address the current limitations and propose future directions and research opportunities to advance the study of BALF.

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来源期刊

PROTEOMICS – Clinical Applications 医学-生化研究方法

CiteScore

5.20

自引率

5.00%

发文量

审稿时长

1 months

期刊介绍： PROTEOMICS - Clinical Applications has developed into a key source of information in the field of applying proteomics to the study of human disease and translation to the clinic. With 12 issues per year, the journal will publish papers in all relevant areas including: -basic proteomic research designed to further understand the molecular mechanisms underlying dysfunction in human disease -the results of proteomic studies dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers -the use of proteomics for the discovery of novel drug targets -the application of proteomics in the drug development pipeline -the use of proteomics as a component of clinical trials.