帕金森病苍白球刺激药物减少的临床和影像学相关性

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-03-18 DOI:10.1002/mdc3.70042

Daniel G Di Luca, Carolina Ramirez-Gomez, Brendan Santyr, Marco Fumagalli, Jürgen Germann, Suneil K Kalia, Andres M Lozano, Alfonso Fasano

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引用次数: 0

摘要

背景：帕金森病（PD）深部脑刺激（DBS）内苍白球（GPi）左旋多巴当量日剂量（LEDD）减少的幅度和相关因素尚不清楚。目的：探讨GPi DBS中LEDD降低及其与解剖/临床特征的关系。方法：对74例GPi DBS患者进行连续队列分析。采用回归和概率效能图来评估预测led降低的因素。结果：32.4%的GPi个体经历了显著的led减少（约30%）。前内侧GPi刺激与较高的LEDD降低相关。结论：前内侧刺激GPi似乎与药物减少有关，挑战了GPi DBS对减少LEDD无效的观点。需要进一步的前瞻性研究来验证这些发现。

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Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease.

Background: The magnitude and factors associated with levodopa equivalent daily dose (LEDD) reduction in deep brain stimulation (DBS) of the globus pallidus interna (GPi) for Parkinson's Disease (PD) remain unclear.

Objective: To investigate LEDD reduction in GPi DBS and its correlation with anatomical/clinical characteristics.

Methods: A consecutive cohort of 74 patients who had undergone GPi DBS was analyzed. Regression and probabilistic efficacy mapping were performed to evaluate factors predicting LEDD reduction.

Results: 32.4% of GPi individuals experienced significant LEDD reduction (>30%). Anteromedial GPi stimulation was associated with higher LEDD reduction.

Conclusion: Anteromedial stimulation of the GPi appears to be associated with medication reduction, challenging the idea that GPi DBS is ineffective at reducing LEDD. Further prospective study will be needed to validate these findings.

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)