韩国三级医院白色念珠菌血液感染和抗真菌耐药性趋势(2013-2023)

IF 2 4区 生物学 Q2 AGRONOMY
Mycobiology Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI:10.1080/12298093.2025.2461336
Ki-Yeon Kim, Ga-Yeon Kim, Jae Kyung Kim
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引用次数: 0

摘要

在这项研究中,我们旨在分析韩国忠清南道一所大学医院11年间(2013 - 2023年)白色念珠菌感染的年度、年龄和性别特异性频率和抗真菌耐药率。回顾性分析了260,769例血培养中鉴定为白色念珠菌的476例。2019年和2022年白色念珠菌年分离株数较上年分别增长161.1%和136.7%。分离出白色念珠菌的患者平均年龄为65.8岁,其中51.8%的患者年龄在60-79岁之间。男性患者的分离株数高于女性患者(男女比例为1.4:1)。对氟胞嘧啶耐药6.6%,对伏立康唑耐药4.5%,对卡泊芬净和米卡芬净均敏感。综上所述,本研究为忠清地区的三级综合医院和制定国家感染管理战略提供了重要的基础数据,从而为未来的深入研究提供了宝贵的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Trends in <i>Candida albicans</i> Bloodstream Infections and Antifungal Resistance in a Tertiary Care Hospital in South Korea (2013-2023).

Trends in <i>Candida albicans</i> Bloodstream Infections and Antifungal Resistance in a Tertiary Care Hospital in South Korea (2013-2023).

Trends in Candida albicans Bloodstream Infections and Antifungal Resistance in a Tertiary Care Hospital in South Korea (2013-2023).

In this study, we aimed to analyze the annual, age- and sex-specific frequencies and antifungal resistance rates of Candida albicans infections over an 11-year period (2013 - 2023) at a university hospital in South Chungcheong Province, South Korea. A total of 476 cases identified as C. albicans from 260,769 blood cultures were analyzed retrospectively. The annual number of C. albicans isolates increased by 161.1% in 2019 and 136.7% in 2022 compared with that in the previous year. The mean age of patients from whom C. albicans was isolated was 65.8 years, with 51.8% patients being aged 60-79 years. The number of isolates was higher in male patients than in female patients (male-to-female ratio: 1.4:1). Of the isolates, 6.6% were resistant to flucytosine and 4.5% were resistant to voriconazole, whereas all isolates were susceptible to caspofungin and micafungin. Overall, this study provides vital foundational data for tertiary general hospitals in the Chungcheong region and for developing national infection management strategies, thereby providing a valuable basis for future in-depth studies.

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来源期刊
Mycobiology
Mycobiology AGRONOMYMYCOLOGY-MYCOLOGY
CiteScore
3.90
自引率
5.30%
发文量
41
审稿时长
22 weeks
期刊介绍: Mycobiology is an international journal devoted to the publication of fundamental and applied investigations on all aspects of mycology and their traditional allies. It is published quarterly and is the official publication of the Korean Society of Mycology. Mycobiology publishes reports of basic research on fungi and fungus-like organisms, including yeasts, filamentous fungi, lichen fungi, oomycetes, moulds, and mushroom. Topics also include molecular and cellular biology, biochemistry, metabolism, developmental biology, environmental mycology, evolution, ecology, taxonomy and systematics, genetics/genomics, fungal pathogen and disease control, physiology, and industrial biotechnology using fungi.
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