变形机制:对白色念珠菌形态发生的多指标综合洞察。

IF 2 4区 生物学 Q2 AGRONOMY
Mycobiology Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI:10.1080/12298093.2025.2460304
Kyunghun Min, Aerin Park
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引用次数: 0

摘要

白色念珠菌在酵母菌、菌丝和假菌丝之间转换的能力是其适应性和致病性的基础。虽然camp依赖性信号一直被认为是菌丝生长的核心,但最近的多组学研究表明,与camp无关的机制也推动了菌丝形态的变化。基础PKA活性、周期蛋白依赖性激酶(如Cdc28)和其他调节因子即使没有经典的cAMP途径也能促进形状变化。此外,n -乙酰氨基葡萄糖(GlcNAc)作为诱导菌丝生长的有效信号,独立于其代谢作用,直接将环境因素与形态状态联系起来。通过整合转录组学、蛋白质组学和磷蛋白质组学数据,本综述揭示了控制白色念珠菌形态发生的复杂网络。对这些复杂调控回路的更清晰理解为未来采用先进的多组学分析的研究奠定了基础。这些方法将有助于阐明这些途径是如何汇聚的,它们如何对不断变化的环境做出反应,以及它们如何被利用或破坏来影响真菌的行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Shape-Shifting Mechanisms: Integrative Multi-Omics Insights Into <i>Candida albicans</i> Morphogenesis.

Shape-Shifting Mechanisms: Integrative Multi-Omics Insights Into <i>Candida albicans</i> Morphogenesis.

Shape-Shifting Mechanisms: Integrative Multi-Omics Insights Into Candida albicans Morphogenesis.

The ability of Candida albicans to switch among yeast, hyphal, and pseudohyphal forms underlies its adaptability and pathogenicity. While cAMP-dependent signaling has long been considered central to hyphal growth, recent multi-omics studies show that cAMP-independent mechanisms also drive morphological changes. Basal PKA activity, cyclin-dependent kinases (e.g., Cdc28), and other regulators can promote shape-shifting even without classical cAMP pathways. In addition, N-acetylglucosamine (GlcNAc) acts as a potent signal that induces hyphal growth independently of its metabolic role, directly connecting environmental cues to morphological states. By integrating transcriptomic, proteomic, and phosphoproteomic data, this review exposes the intricate networks controlling C. albicans morphogenesis. A clearer understanding of these complex regulatory circuits lays the groundwork for future studies that employ advanced multi-omics analyses. Such approaches will help elucidate how these pathways converge, how they respond to changing environments, and how they might be harnessed or disrupted to influence fungal behavior.

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来源期刊
Mycobiology
Mycobiology AGRONOMYMYCOLOGY-MYCOLOGY
CiteScore
3.90
自引率
5.30%
发文量
41
审稿时长
22 weeks
期刊介绍: Mycobiology is an international journal devoted to the publication of fundamental and applied investigations on all aspects of mycology and their traditional allies. It is published quarterly and is the official publication of the Korean Society of Mycology. Mycobiology publishes reports of basic research on fungi and fungus-like organisms, including yeasts, filamentous fungi, lichen fungi, oomycetes, moulds, and mushroom. Topics also include molecular and cellular biology, biochemistry, metabolism, developmental biology, environmental mycology, evolution, ecology, taxonomy and systematics, genetics/genomics, fungal pathogen and disease control, physiology, and industrial biotechnology using fungi.
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