{"title":"含有益生菌的饲料添加剂对慢性肾病和肠道疾病犬的粪便评分和临床指标的影响:试点研究。","authors":"Francesca Perondi, Ilaria Lippi, Natascia Bruni, Nicolò Lonigro, And Elisa Martello","doi":"10.5455/OVJ.2024.v15.i1.29","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including <i>Lactobacillus acidophilus</i>, <i>Enterococcus faecium</i>, and <i>Saccharomyces cerevisiae</i>, have shown promise in maintaining a healthy gut microbiota in both healthy and CKD animals.</p><p><strong>Aim: </strong>This pilot double-blinded, randomized controlled study aimed to assess the effects of a feed supplement containing these probiotics on clinical parameters and fecal consistency in dogs with CKD and intestinal disorders.</p><p><strong>Methods: </strong>Eight dogs with CKD were randomly assigned to receive the supplement (TRT, <i>n</i> = 4) or placebo (CTR, <i>n</i> = 4) alongside a renal commercial complete dietetic feed and another supplement specific for CKD for 50 days. Clinical parameters, such as body condition score and fecal score, were regularly monitored.</p><p><strong>Results: </strong>The dogs in the TRT group exhibited improvements in fecal consistency and clinical parameters compared with the CTR group.</p><p><strong>Conclusion: </strong>The feed supplement under investigation seems beneficial for improving clinical conditions, gut health, and stool quality in dogs with CKD. Future studies with larger sample sizes and microbiota analyses are needed to gain a better understanding of the potential benefits of this supplement in managing CKD in dogs.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"15 1","pages":"307-313"},"PeriodicalIF":0.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910283/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study.\",\"authors\":\"Francesca Perondi, Ilaria Lippi, Natascia Bruni, Nicolò Lonigro, And Elisa Martello\",\"doi\":\"10.5455/OVJ.2024.v15.i1.29\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including <i>Lactobacillus acidophilus</i>, <i>Enterococcus faecium</i>, and <i>Saccharomyces cerevisiae</i>, have shown promise in maintaining a healthy gut microbiota in both healthy and CKD animals.</p><p><strong>Aim: </strong>This pilot double-blinded, randomized controlled study aimed to assess the effects of a feed supplement containing these probiotics on clinical parameters and fecal consistency in dogs with CKD and intestinal disorders.</p><p><strong>Methods: </strong>Eight dogs with CKD were randomly assigned to receive the supplement (TRT, <i>n</i> = 4) or placebo (CTR, <i>n</i> = 4) alongside a renal commercial complete dietetic feed and another supplement specific for CKD for 50 days. Clinical parameters, such as body condition score and fecal score, were regularly monitored.</p><p><strong>Results: </strong>The dogs in the TRT group exhibited improvements in fecal consistency and clinical parameters compared with the CTR group.</p><p><strong>Conclusion: </strong>The feed supplement under investigation seems beneficial for improving clinical conditions, gut health, and stool quality in dogs with CKD. Future studies with larger sample sizes and microbiota analyses are needed to gain a better understanding of the potential benefits of this supplement in managing CKD in dogs.</p>\",\"PeriodicalId\":19531,\"journal\":{\"name\":\"Open Veterinary Journal\",\"volume\":\"15 1\",\"pages\":\"307-313\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910283/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Veterinary Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/OVJ.2024.v15.i1.29\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Veterinary Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/OVJ.2024.v15.i1.29","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study.
Background: Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including Lactobacillus acidophilus, Enterococcus faecium, and Saccharomyces cerevisiae, have shown promise in maintaining a healthy gut microbiota in both healthy and CKD animals.
Aim: This pilot double-blinded, randomized controlled study aimed to assess the effects of a feed supplement containing these probiotics on clinical parameters and fecal consistency in dogs with CKD and intestinal disorders.
Methods: Eight dogs with CKD were randomly assigned to receive the supplement (TRT, n = 4) or placebo (CTR, n = 4) alongside a renal commercial complete dietetic feed and another supplement specific for CKD for 50 days. Clinical parameters, such as body condition score and fecal score, were regularly monitored.
Results: The dogs in the TRT group exhibited improvements in fecal consistency and clinical parameters compared with the CTR group.
Conclusion: The feed supplement under investigation seems beneficial for improving clinical conditions, gut health, and stool quality in dogs with CKD. Future studies with larger sample sizes and microbiota analyses are needed to gain a better understanding of the potential benefits of this supplement in managing CKD in dogs.
期刊介绍:
Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.