晚期前列腺癌的卫星DNA扩增在很大程度上独立于常染色质扩增和癌基因扩增。

IF 1.9 4区生物学 Q4 CELL BIOLOGY

Journal of Histochemistry & Cytochemistry Pub Date : 2025-03-17 DOI:10.1369/00221554251323657

Anja Weise, Antonio Augusto Ornellas, Gilda Alves, Constanze Pentzold, Jenny Holler, Melanie Wolter, Elena Jamali, Bernhard Theis, Thomas Liehr

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引用次数: 0

摘要

最近，我们能够证明卫星DNA扩增（satDNA-AMP）存在于晚期前列腺癌中。染色体微阵列研究提供了第一个证据，表明satDNA-AMP似乎在很大程度上独立于着丝粒附近/中心周围的常染色质拷贝数改变。因此，我们可以谨慎地认为，satDNA-AMP可能是一种新的、独立的肿瘤进展标志物。

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Satellite DNA Amplification in Advanced Prostate Cancer Is Largely Independent From Euchromatic and Oncogene Amplicons.

Recently, we were able to show that satellite DNA amplification (satDNA-AMP) is present in advanced prostate cancer. A chromosome microarray study provided first evidence that satDNA-AMP appears to be largely independent of centromere-near/pericentric euchromatic copy number alterations. Therefore, it might be carefully suggested that satDNA-AMP could be a new and independent marker for advanced tumor progression.

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来源期刊

Journal of Histochemistry & Cytochemistry 生物-细胞生物学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Journal of Histochemistry & Cytochemistry (JHC) has been a pre-eminent cell biology journal for over 50 years. Published monthly, JHC offers primary research articles, timely reviews, editorials, and perspectives on the structure and function of cells, tissues, and organs, as well as mechanisms of development, differentiation, and disease. JHC also publishes new developments in microscopy and imaging, especially where imaging techniques complement current genetic, molecular and biochemical investigations of cell and tissue function. JHC offers generous space for articles and recognizing the value of images that reveal molecular, cellular and tissue organization, offers free color to all authors.