{"title":"新疆乌鲁木齐市宫颈细胞学异常妇女人乳头瘤病毒流行及基因型分布","authors":"Jing Ma, Min Yang, Guohong Huang","doi":"10.1002/dc.25467","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.</p><p><strong>Methods: </strong>The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.</p><p><strong>Result: </strong>The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.</p><p><strong>Conclusion: </strong>Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in Urumqi, Xinjiang, China.\",\"authors\":\"Jing Ma, Min Yang, Guohong Huang\",\"doi\":\"10.1002/dc.25467\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.</p><p><strong>Methods: </strong>The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.</p><p><strong>Result: </strong>The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.</p><p><strong>Conclusion: </strong>Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.</p>\",\"PeriodicalId\":11349,\"journal\":{\"name\":\"Diagnostic Cytopathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic Cytopathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/dc.25467\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/dc.25467","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in Urumqi, Xinjiang, China.
Objective: To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.
Methods: The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.
Result: The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.
Conclusion: Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.
期刊介绍：
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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